RESEARCH NEWS 2016-02-09 Research News A kinase inhibitor that is an approved medication for people and improves memory in rats also promotes degradation of toxic tau in lab models, according to a paper in the January 27 Journal of Neuroscience. Inhibiting the Rho-associated ...
PAPER Huentelman MJ, Stephan DA, Talboom J, Corneveaux JJ, Reiman DM, Gerber JD, Barnes CA, Alexander GE, Reiman EM, Bimonte-Nelson HA19170447
PAPER Tönges L, Frank T, Tatenhorst L, Saal KA, Koch JC, Szego ÉM, Bähr M, Weishaupt JH, Lingor P
Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease.Brain. 2012 Nov;135(Pt 11):3355-70. Epub 2012 Oct 19 PubMed: 23087045
PAPER Enomoto Y, Yoshimura S, Yamada K, Iwama T
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PAPER Ishihara M, Yamanaka K, Nakajima S, Yamasaki M
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PAPER Shi J, Wei L23921309
COMMENT I would like to thank Dr. Trushina for her comment, while also pointing out that our methods for sample collection, processing, and storage are outlined in the supplemental material of our manuscript. I direct the Alzforum audience's attention to the ...
Gerd Pfeifer on Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration.
COMMENT I agree with the comments on Jin et al (2016). The binding of this Tet3 isoform to lysosomal and autophagy genes is quite specific. There must be a selective recruitment process. We are now studying Tet3 localization and function in young and aging brain ...
Virgil Muresan on Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits.
COMMENT This paper by Xu et al. is another example that rodent Aβ not only can, but indeed does, aggregate, and does produce amyloid deposits in vivo. That the primary sequence of rodent Aβ is compatible with aggregation of the peptide into amyloid plaques ...
PAPER Danova D2562573
JOB 2016-02-08 Employer Massachusetts Alzheimer’s Disease Research Center/Massachusetts Genera; Hospital Neurology Contact email@example.com Description The Massachusetts Alzheimer's Disease Research Center (ADRC) is pleased to announce an opening for a two ...
COMMENT Overall, results in the CCS/SOD mice look very promising, and are consistent with other experimental data that support the concept that altering copper levels in the CNS might have some therapeutic benefits in specific conditions. This could also include ...
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