PAPER Choi J, Lee HW, Suk K

Increased plasma levels of lipocalin 2 in mild cognitive impairment.

J Neurol Sci. 2011 Jun 15;305(1-2):28-33. PubMed: 21463871

PAPER Rapp T, Grand A, Cantet C, Andrieu S, Coley N, Portet F, Vellas B

Public financial support receipt and non-medical resource utilization in Alzheimer's disease results from the PLASA study.

Soc Sci Med. 2011 Apr;72(8):1310-6. PubMed: 21463914

PAPER Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M

Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking.

Mol Cell Biol. 2011 Jun;31(11):2326-40. PubMed: 21464208

PAPER Itkin A, Dupres V, Dufrêne YF, Bechinger B, Ruysschaert JM, Raussens V

Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease.

PLoS One. 2011;6(3):e18250. PubMed: 21464905

PAPER Pinton S, da Rocha JT, Gai BM, Prigol M, da Rosa LV, Nogueira CW

Neuroprotector effect of p,p'-methoxyl-diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism.

Cell Biochem Funct. 2011 Apr;29(3):235-43. PubMed: 21465495

PAPER Romero-Curiel A, López-Carpinteyro D, Gamboa C, de la Cruz F, Zamudio S, Flores G

Apamin induces plastic changes in hippocampal neurons in senile Sprague-Dawley rats.

Synapse. 2011 Oct;65(10):1062-72. PubMed: 21465567

PAPER Gupta-Rossi N, Ortica S, Meas-Yedid V, Heuss S, Moretti J, Olivo-Marin JC, Israël A

The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway.

J Biol Chem. 2011 May 27;286(21):18720-30. PubMed: 21464124

PAPER Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.

Autophagy. 2011 Jul;7(7):788-9. PubMed: 21464620

Cornelius J Donnelly

Freelance Funding
Vero Beach, United States

PAPER Bartus RT, Herzog CD, Chu Y, Wilson A, Brown L, Siffert J, Johnson EM, Olanow CW, Mufson EJ, Kordower JH

Bioactivity of AAV2-neurturin gene therapy (CERE-120): differences between Parkinson's disease and nonhuman primate brains.

Mov Disord. 2011 Jan;26(1):27-36. PubMed: 21322017

PAPER Barhum Y, Gai-Castro S, Bahat-Stromza M, Barzilay R, Melamed E, Offen D

Intracerebroventricular transplantation of human mesenchymal stem cells induced to secrete neurotrophic factors attenuates clinical symptoms in a mouse model of multiple sclerosis.

J Mol Neurosci. 2010 May;41(1):129-37. PubMed: 19902385

PAPER Brundin P, Barker RA, Parmar M

Neural grafting in Parkinson's disease Problems and possibilities.

Prog Brain Res. 2010;184:265-94. PubMed: 20887880

PAPER Kirik D, Björklund A

Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results.

Brain. 2005 Jul;128(Pt 7):1478-9. PubMed: 15980119

Roberto Malinow on Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β.

COMMENT This study nicely examines potential signaling activated by β amyloid that could perturb LTP. The signaling identified can play multiple roles, so their exact participation in the effects of β amyloid needs to be elucidated. As targets for Alzheimer'

Barcelona: Is Parkinson’s Pathology Treatable?

CONFERENCE COVERAGE 2011-04-06 Conference Coverage Short answer: Not yet. But scientists are hammering away at the problem, and this series features progress reports on some experimental PD therapies. For Parkinson’s disease, unlike Alzheimer’s, physicians have numerous effective treat