COMMENT There were some references in this Webinar to the need for more mechanism-based modeling. Someone asked whether modeling and simulation had been able to (ever) identify possible hypotheses for unexpected outcomes in CNS diseases. With our mechanism-based ...
PAPER Spiros A, Roberts P, Geerts H
A computer-based quantitative systems pharmacology model of negative symptoms in schizophrenia: exploring glycine modulation of excitation-inhibition balance.Front Pharmacol. 2014;5:229. Epub 2014 Oct 21 PubMed: 25374541
PAPER Nicholas T, Sridhar Duvvuri S, Leurent C, Raunig D, Rapp T, Iredale P, Rowinski C, Carr R, Patrick R, Spiros A, Geerts H
COMMENT Ayton et al. published interesting data on CSF ferritin as a biomarker for AD. Based on the cognitive data, the authors conclude that ferritin is a trait marker because it correlates cross-sectionally with cognitive scores, but not with change in ...
Steve Barger on d-serine levels in Alzheimer's disease: implications for novel biomarker development.
COMMENT Excitatory amino acids (EAA) have a long and complex history in AD research. Considerable evidence exists for EAA dysregulation in AD pathogenesis, including depletion of the so-called “glycine B ” component of the NMDA receptor (Procter et al., 1989). ...
PAPER Schütz B
Imbalanced excitatory to inhibitory synaptic input precedes motor neuron degeneration in an animal model of amyotrophic lateral sclerosis.Neurobiol Dis. 2005 Oct;20(1):131-40. PubMed: 16137574
PAPER Labrie V, Fukumura R, Rastogi A, Fick LJ, Wang W, Boutros PC, Kennedy JL, Semeralul MO, Lee FH, Baker GB, Belsham DD, Barger SW, Gondo Y, Wong AH, Roder JC19483194
PAPER Nagata Y, Borghi M, Fisher GH, D'Aniello A7583345
PAPER Chouinard ML, Gaitan D, Wood PL
Presence of the N-methyl-D-aspartate-associated glycine receptor agonist, D-serine, in human temporal cortex: comparison of normal, Parkinson, and Alzheimer tissues.J Neurochem. 1993 Oct;61(4):1561-4. PubMed: 8397299
PAPER Wu S, Barger SW15681805
PAPER Barger SW, Goodwin ME, Porter MM, Beggs ML17403030
PAPER Procter AW, Wong EH, Stratmann GC, Lowe SL, Bowen DM2569500
Universidad del TuraboGurabo, Puerto Rico
CONFERENCE 2016-01-24 00:00:00-2016-01-27 00:00:00 Eldorado Hotel & Spa, Santa Fe, New Mexico 24 – 27 January 2016 This Keystone Symposia meeting will bring together scientists from multiple disciplines interested in addressing problems rooted in axonal cell biology, such as intracellular ...
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