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Australia Report: Lessons From a Clinical Trial—Too Little Too Late

CONFERENCE COVERAGE 2011-10-13 Conference Coverage This meeting could not avoid a discussion of semagacestat/LY450139, a γ-secretase inhibitor whose development ended in 2010 following cognitive worsening and other side effects in Phase 3. The pharmacology of semagacestat included a re

Tracking Huntington’s: Could Histone Protein Hit The Mark?

RESEARCH NEWS 2011-10-13 Research News In the quest for a Huntington’s disease biomarker—one that reliably tracks disease progress and therapeutic response—researchers have so far come up short. Behavioral tests, neuroimages, and cerebrospinal fluid markers, which are panning out

Could Asking People How They Feel Help Predict Dementia?

RESEARCH NEWS 2011-10-13 Research News Imaging the living brain, searching for telltale molecules in the cerebrospinal fluid, and measuring memory and thinking skills—these are among the tests scientists use to figure out who might eventually develop Alzheimer’s disease (AD). But

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