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Natalie Marchant on Arterial stiffness and β-amyloid progression in nondemented elderly adults.
COMMENT The study by Hughes and colleagues highlights the utility of longitudinal amyloid imaging and pulse wave velocity (PWD) to measure arterial stiffness. By capitalizing on the relatively consistent age-related upward trajectory of PWD, the authors demonstra
Roxana Carare, Roy Weller on Arterial stiffness and β-amyloid progression in nondemented elderly adults.
COMMENT Our group has demonstrated that interstitial fluid and solutes are cleared from the brain by bulk flow along the basement membranes of capillary and artery walls, analogous to the lymphatics of other organs (1). In aging, fibrils of amyloid accumulate in
Can Arterial Health Predict Amyloid Deposition?
RESEARCH NEWS 2014-04-04 Research News In case you needed it, here’s another incentive to take good care of your cardiovascular system. In the March 31 JAMA Neurology, researchers led by Timothy Hughes at Wake Forest School of Medicine, Winston-Salem, North Carolina, reported tha
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Cardiol Rev. 2012 Sep-Oct;20(5):259-63. PubMed: 22573107PAPER Hughes TM, Kuller LH, Barinas-Mitchell EJ, Mackey RH, McDade EM, Klunk WE, Aizenstein HJ, Cohen AD, Snitz BE, Mathis CA, Dekosky ST, Lopez OL
Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults.
Neurology. 2013 Nov 5;81(19):1711-8. Epub 2013 Oct 16 PubMed: 24132374PAPER Zeki Al Hazzouri A, Newman AB, Simonsick E, Sink KM, Sutton Tyrrell K, Watson N, Satterfield S, Harris T, Yaffe K, Health ABC Study
Pulse wave velocity and cognitive decline in elders: the Health, Aging, and Body Composition study.
Stroke. 2013 Feb;44(2):388-93. Epub 2013 Jan 15 PubMed: 23321445PAPER Benetos A, Watfa G, Hanon O, Salvi P, Fantin F, Toulza O, Manckoundia P, Agnoletti D, Labat C, Gautier S, PARTAGE Study Investigators
Pulse wave velocity is associated with 1-year cognitive decline in the elderly older than 80 years: the PARTAGE study.
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Arterial stiffness and cognitive decline in well-functioning older adults.
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The Scientist. 2004 Dec 8;18(23):6.Mathieu Verdurand
Lyon Hospitals (HCL), Lyon Neuroscience Research Center (CNRS UMR5292 INSERM U1028)Lyon, France
PAPER Ghosh AK, Osswald HL
BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease.
Chem Soc Rev. 2014 Sep 8;43(19):6765-813. PubMed: 24691405Current Filters
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