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Loss of Y Chromosome in Blood Tied to Alzheimer’s Disease

RESEARCH NEWS 2016-05-26 Research News The runt of the chromosome litter may have more to its bite than simply determining male sex. According to a study published June 2 in The American Journal of Human Genetics, loss of the Y chromosome in a fraction of blood cells drove up men ...

PAPER Zhou W, Machiela MJ, Freedman ND, Rothman N, Malats N, Dagnall C, Caporaso N, Teras LT, Gaudet MM, Gapstur SM, Stevens VL, Jacobs KB, Sampson J, Albanes D, Weinstein S, Virtamo J, Berndt S, Hoover RN, Black A, Silverman D, Figueroa J, Garcia-Closas M, Real FX, Earl J, Marenne G, Rodriguez-Santiago B, Karagas M, Johnson A, Schwenn M, Wu X, Gu J, Ye Y, Hutchinson A, Tucker M, Perez-Jurado LA, Dean M, Yeager M, Chanock SJ

Mosaic loss of chromosome Y is associated with common variation near TCL1A.

Nat Genet. 2016 May;48(5):563-8. Epub 2016 Apr 11 PubMed: 27064253

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