PAPER Nisbet RM, Harrison CF, Lawson VA, Masters CL, Cappai R, Hill AF

Residues surrounding the glycosylphosphatidylinositol anchor attachment site of PrP modulate prion infection: insight from the resistance of rabbits to prion disease.

J Virol. 2010 Jul;84(13):6678-86. PubMed: 20427543

PAPER Blalock EM, Grondin R, Chen KC, Thibault O, Thibault V, Pandya JD, Dowling A, Zhang Z, Sullivan P, Porter NM, Landfield PW

Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys.

J Neurosci. 2010 Apr 28;30(17):6058-71. PubMed: 20427664

PAPER Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, Ogasawara K, Hirano A, Takumi T, Kusaka H, Hagiwara K, Kaji R, Kawakami H

Mutations of optineurin in amyotrophic lateral sclerosis.

Nature. 2010 May 13;465(7295):223-6. PubMed: 20428114

PAPER Doo AR, Kim ST, Kim SN, Moon W, Yin CS, Chae Y, Park HK, Lee H, Park HJ

Neuroprotective effects of bee venom pharmaceutical acupuncture in acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.

Neurol Res. 2010 Feb;32 Suppl 1:88-91. PubMed: 20034453

PAPER Di Stefano G, Casoli T, Platano D, Fattoretti P, Balietti M, Giorgetti B, Bertoni-Freddari C, Lattanzio F, Aicardi G

Differences in gene expression in the hippocampus of aged rats are associated with better long-term memory performance in a passive avoidance test.

Rejuvenation Res. 2010 Apr-Jun;13(2-3):224-8. PubMed: 20426624

PAPER Gomi H, Sassa T, Thompson RF, Itohara S

Involvement of cyclin-dependent kinase-like 2 in cognitive function required for contextual and spatial learning in mice.

Front Behav Neurosci. 2010;4:17. PubMed: 20428496

PAPER Bellettato CM, Scarpa M

Pathophysiology of neuropathic lysosomal storage disorders.

J Inherit Metab Dis. 2010 Aug;33(4):347-62. PubMed: 20429032

Volker Doetsch on Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.

COMMENT These authors take one of the helices of presenilin at a time, replace it with a helix of an unrelated protein and then measure its function. If the helix they exchange is important for a certain function, then the modified presenilin should no longer be

Volker Doetsch

Germany

Michael Wolfe on Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.

COMMENT This report provides a very thorough and systematic analysis of the role of the various transmembrane domains of PS1 in γ-secretase assembly, stability and activation. The evidence largely supports the role of specific TM domains in the various steps in t

PAPER Halawani D, Tessier S, Anzellotti D, Bennett DA, Latterich M, Leblanc AC

Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation.

J Neurosci. 2010 Apr 28;30(17):6132-42. PubMed: 20427671

PAPER Kurup P, Zhang Y, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn AC, Lombroso PJ

Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61.

J Neurosci. 2010 Apr 28;30(17):5948-57. PubMed: 20427654

Rebecca Rossom

Minneapolis VA; University of Minnesota
Minneapolis, United States

Peter Atkinson

Eisai Limited
Hatfield

PAPER Deng W, Aimone JB, Gage FH

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

Nat Rev Neurosci. 2010 May;11(5):339-50. PubMed: 20354534