Aβ Vaccine Leads to Safer Immune Response in Mice

RESEARCH NEWS 2013-04-25 Research News A newly developed active amyloid-β vaccine removes Aβ from mouse brains while reducing inflammation and improving cognition, according to results published in the April 17 Journal of Neuroscience. Cynthia Lemere and colleagues at Brigham and

PAPER Yang F, Yang YP, Mao CJ, Liu L, Zheng HF, Hu LF, Liu CF

Crosstalk between the proteasome system and autophagy in the clearance of α-synuclein.

Acta Pharmacol Sin. 2013 May;34(5):674-80. PubMed: 23603979

PAPER Gruschus JM, Yap TL, Pistolesi S, Maltsev AS, Lee JC

NMR Structure of Calmodulin Complexed to an N-Terminally Acetylated α-Synuclein Peptide.

Biochemistry. 2013 May 8; PubMed: 23607618

PAPER Coskuner O, Wise-Scira O

Structures and Free Energy Landscapes of the A53T Mutant-Type α-Synuclein Protein and Impact of A53T Mutation on the Structures of the Wild-Type α-Synuclein Protein with Dynamics.

ACS Chem Neurosci. 2013 May 17; PubMed: 23607785

PAPER Varkey J, Mizuno N, Hegde BG, Cheng N, Steven AC, Langen R

α-Synuclein Oligomers with Broken Helical Conformation Form Lipoprotein Nanoparticles.

J Biol Chem. 2013 Jun 14;288(24):17620-30. PubMed: 23609437

PAPER Chinta SJ, Lieu CA, Demaria M, Laberge RM, Campisi J, Andersen JK

Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?

J Intern Med. 2013 May;273(5):429-36. PubMed: 23600398

Jiu-Chiuan (J.C.) Chen

University of Southern California, Keck School of Medicine
Los Angeles, United States

PAPER Gurney ME, Liu R, Althaus JS, Hall ED, Becker DA

Mutant Cu,Zn superoxide dismutase in motor neuron disease.

Age (Omaha). 1998 Apr;21(2):85-9. PubMed: 23604357

PAPER Kandinov B, Grigoriadis NC, Touloumi O, Drory VE, Offen D, Korczyn AD

Immunohistochemical analysis of sympathetic involvement in the SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 Apr 23; PubMed: 23607704

PAPER Mead RJ, Higginbottom A, Allen SP, Kirby J, Bennett E, Barber SC, Heath PR, Coluccia A, Patel N, Gardner I, Brancale A, Grierson AJ, Shaw PJ

S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis.

Free Radic Biol Med. 2013 Apr 19;61C:438-452. PubMed: 23608463

PAPER Decressac M, Mattsson B, Weikop P, Lundblad M, Jakobsson J, Björklund A

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1817-26. Epub 2013 Apr 22 PubMed: 23610405

PAPER Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM

CLP1 links tRNA metabolism to progressive motor-neuron loss.

Nature. 2013 Mar 28;495(7442):474-80. PubMed: 23474986

PAPER Faria C, Jorge CD, Borges N, Tenreiro S, Outeiro TF, Santos H

Inhibition of formation of α-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease.

Biochim Biophys Acta. 2013 Aug;1830(8):4065-72. PubMed: 23608058

PAPER Chung JY, Park HR, Lee SJ, Lee SH, Kim JS, Jung YS, Hwang SH, Ha NC, Seol WG, Lee J, Park BJ

Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.

Lab Invest. 2013 Jun;93(6):663-76. PubMed: 23608757

PAPER Caillierez R, Bégard S, Lécolle K, Deramecourt V, Zommer N, Dujardin S, Loyens A, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Buée L, Colin M

Lentiviral Delivery of the Human Wild-type Tau Protein Mediates a Slow and Progressive Neurodegenerative Tau Pathology in the Rat Brain.

Mol Ther. 2013 Jul;21(7):1358-68. PubMed: 23609018