PAPER Spencer RM, Gouw AM, Ivry RB

Age-related decline of sleep-dependent consolidation.

Learn Mem. 2007 Jul;14(7):480-4. PubMed: 17622650

PAPER Gerrard JL, Burke SN, McNaughton BL, Barnes CA

Sequence reactivation in the hippocampus is impaired in aged rats.

J Neurosci. 2008 Jul 30;28(31):7883-90. PubMed: 18667620

PAPER Dumas J, Hancur-Bucci C, Naylor M, Sites C, Newhouse P

Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: evidence for the critical period hypothesis.

Horm Behav. 2008 Jan;53(1):159-69. PubMed: 17964576

Patrick May on Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor.

COMMENT LY2811376 represents a breakthrough in targeting BACE1, the protease that initiates the amyloid cascade. After 10 years of research, many in the field were beginning to question whether this critical protease could be targeted with a small-molecule inhibi

PAPER May PC, Dean RA, Lowe SL, Martenyi F, Sheehan SM, Boggs LN, Monk SA, Mathes BM, Mergott DJ, Watson BM, Stout SL, Timm DE, Smith Labell E, Gonzales CR, Nakano M, Jhee SS, Yen M, Ereshefsky L, Lindstrom TD, Calligaro DO, Cocke PJ, Greg Hall D, Friedrich S, Citron M, Audia JE

Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor.

J Neurosci. 2011 Nov 16;31(46):16507-16. PubMed: 22090477

Garth Hall on In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice.

COMMENT This is a very ingenious demonstration that significant extracellular human tau levels exist and can be monitored in transgenic mice. It is particularly important because it opens the door to a detailed biochemical characterization of the secretion proces

Abhay Sagare on Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.

COMMENT This paper by Selkoe’s group is an important contribution to our understanding of amyloid-β (Aβ), an Alzheimer’s disease (AD) neurotoxin metabolism in plaque-free and plaque-rich brain. The authors used a well-established microdialysis technique to study

PAPER George CF, Gruchy BS

Elimination of drugs by active intestinal transport.

J Pharm Pharmacol. 1979 Sep;31(9):643-4. PubMed: 41074

In Healthy Brains, Does Aβ Really Matter?

RESEARCH NEWS 2011-11-18 Research News Amyloid plaque buildup in the brain is one of the hallmarks of Alzheimer's disease. But one perplexing aspect of amyloid pathology, known for decades from autopsy findings (see Crystal et al., 1988), is that many cognitively normal peop

DC: Ways to Slow Brain Aging: Exercise, Estrogen, and Sleep?

CONFERENCE COVERAGE 2011-11-18 Conference Coverage Aging brains slow down just as aging bodies do, but growing research indicates that people can influence the way their brains age. In a November 13 press conference at the Society for Neuroscience 2011 annual meeting, held 12-16 Novemb

DC: New ALS Genetics Hog the Limelight at Satellite Conference

CONFERENCE COVERAGE 2011-11-18 Conference Coverage Researchers studying amyotrophic lateral sclerosis and other diseases related to RNA-binding proteins gathered in Arlington, Virginia, 10-11 November 2011, to revel in, amongst other things, widespread excitement about new genes recent

Clinical Trials: Making “Protocols From Hell” Less Burdensome

CONFERENCE COVERAGE 2011-11-18 Conference Coverage Here is a typical scenario. A big trial ends, the sponsor announces success or failure, the researchers describe the findings at conferences, and if the press takes an interest in the story, the results may end up on the evening news.

PAPER Bian C, Zhu K, Guo Q, Xiong Y, Cai W, Zhang J

Sex differences and synchronous development of steroid receptor coactivator-1 and synaptic proteins in the hippocampus of postnatal female and male C57BL/6 mice.

Steroids. 2012 Jan;77(1-2):149-56. PubMed: 22085911

PAPER Kiss A, Delattre AM, Pereira SI, Carolino RG, Szawka RE, Anselmo-Franci JA, Zanata SM, Ferraz AC

17β-estradiol replacement in young, adult and middle-aged female ovariectomized rats promotes improvement of spatial reference memory and an antidepressant effect and alters monoamines and BDNF levels in memory- and depression-related brain areas.

Behav Brain Res. 2012 Feb 1;227(1):100-8. PubMed: 22085882

PAPER Oberländer U, Pletinckx K, Döhler A, Müller N, Lutz MB, Arzberger T, Riederer P, Gerlach M, Koutsilieri E, Scheller C

Neuromelanin is an immune stimulator for dendritic cells in vitro.

BMC Neurosci. 2011;12:116. PubMed: 22085464