Soothing Neuroinflammation Quells Plaques in Mice

RESEARCH NEWS 2012-11-29 Research News Just as turning down the gas lowers the heat in the kitchen, dialing back an inflammatory signaling pathway quenches amyloid-β in the brain, according to the November 25 Nature Medicine. Scientists led by Burkhard Becher, University of Zuric

PAPER Guerreiro PS, Huang Y, Gysbers A, Cheng D, Gai WP, Outeiro TF, Halliday GM

LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models.

J Mol Med (Berl). 2012 Nov 27; PubMed: 23183827

PAPER Ozansoy M, Başak AN

The Central Theme of Parkinson's Disease: α-Synuclein.

Mol Neurobiol. 2012 Nov 23; PubMed: 23180276

PAPER Goedert M, Spillantini MG, Del Tredici K, Braak H

100 years of Lewy pathology.

Nat Rev Neurol. 2013 Jan;9(1):13-24. PubMed: 23183883

PAPER Westphal CH, Chandra SS

Monomeric synucleins generate membrane curvature.

J Biol Chem. 2013 Jan 18;288(3):1829-40. Epub 2012 Nov 26 PubMed: 23184946

PAPER Haack TB, Hogarth P, Kruer MC, Gregory A, Wieland T, Schwarzmayr T, Graf E, Sanford L, Meyer E, Kara E, Cuno SM, Harik SI, Dandu VH, Nardocci N, Zorzi G, Dunaway T, Tarnopolsky M, Skinner S, Frucht S, Hanspal E, Schrander-Stumpel C, Héron D, Mignot C, Garavaglia B, Bhatia K, Hardy J, Strom TM, Boddaert N, Houlden HH, Kurian MA, Meitinger T, Prokisch H, Hayflick SJ

Exome sequencing reveals de novo WDR45 mutations causing a phenotypically distinct, X-linked dominant form of NBIA.

Am J Hum Genet. 2012 Dec 7;91(6):1144-9. PubMed: 23176820

PAPER Hadzhieva M, Kirches E, Wilisch-Neumann A, Pachow D, Wallesch M, Schoenfeld P, Paege I, Vielhaber S, Petri S, Keilhoff G, Mawrin C

Dysregulation of iron protein expression in the G93A model of amyotrophic lateral sclerosis.

Neuroscience. 2013 Jan 29;230:94-101. PubMed: 23178912

PAPER Gui YX, Xu ZP, Wen-Lv, Liu HM, Zhao JJ, Hu XY

Four novel rare mutations of PLA2G6 in Chinese population with Parkinson's disease.

Parkinsonism Relat Disord. 2013 Jan;19(1):21-6. PubMed: 23182313

PAPER Scott EL, Zhang QG, Han D, Desai BN, Brann DW

Long-term estrogen deprivation leads to elevation of Dickkopf-1 and dysregulation of Wnt/β-Catenin signaling in hippocampal CA1 neurons.

Steroids. 2012 Nov 22; PubMed: 23178162

PAPER Anneken JH, Cunningham JI, Collins SA, Yamamoto BK, Gudelsky GA

MDMA Increases Glutamate Release and Reduces Parvalbumin-Positive GABAergic Cells in the Dorsal Hippocampus of the Rat: Role of Cyclooxygenase.

J Neuroimmune Pharmacol. 2012 Nov 18; PubMed: 23179355

PAPER Hee Ahn E, Won Kim D, Jea Shin M, Nam Kim Y, Ri Kim H, Jung Woo S, Mi Kim S, Kim DS, Kim J, Park J, Sik Eum W, Hwang HS, Choi SY

PEP-1-ribosomal protein S3 protects dopaminergic neurons in an MPTP-induced Parkinson's disease mouse model.

Free Radic Biol Med. 2013 Feb;55:36-45. PubMed: 23178948

PAPER Ritz K, van Buchem MA, Daemen MJ

The heart-brain connection: mechanistic insights and models.

Neth Heart J. 2013 Feb;21(2):55-7. PubMed: 23179612

PAPER Tortelli R, Conforti FL, Cortese R, D'Errico E, Distaso E, Mazzei R, Ungaro C, Magariello A, Gambardella A, Logroscino G, Simone IL

Amyotrophic lateral sclerosis: a new missense mutation in the SOD1 gene.

Neurobiol Aging. 2013 Jun;34(6):1709.e3-5. Epub 2012 Nov 22 PubMed: 23182243

PAPER Weidenfeld J, Siegal T, Ovadia H

Delayed effects of brain irradiation--part 1: adrenocortical axis dysfunction and hippocampal damage in an adult rat model.

Neuroimmunomodulation. 2013;20(1):57-64. PubMed: 23183099

PAPER Li X, Lee J, Parsons D, Janaurajs K, Standaert DG

Evaluation of TorsinA as a target for Parkinson disease therapy in mouse models.

PLoS One. 2012;7(11):e50063. PubMed: 23185535