PAPER Klann E, Dever TE
SEARCH RESULTS
331009 RESULTS
Gunnar Gouras on Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway.
COMMENT This is a very nice study using high-level microscopy to provide evidence for BACE1 and APP converging in dendritic endosomes of cultured neurons by live cell imaging following synaptic activation. It is less clear what this work means for Alzheimer’s dis
Yasuyuki Mitani on Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production.
COMMENT The finding of a decrease in the AICD 49-99/50-99 ratio due to APP mutations near the γ- or ε-site is intriguing, and may partly answer why these mutations increase the Aβ 42/40 ratio if the step-wise cleavage hypothesis is correct. That GSMs have no effe