Juan Hui

China

Nandini Raghavan on New Frontier: Developing Outcome Measures for Pre-dementia Trials

COMMENT This is a timely discussion, as there is currently a lot of excitement around this topic. Pharma, academia, and regulatory agencies are all trying to work together to make progress in this area. The idea of deconstructing specific instruments like the ADA

Packed in Crystals, Bapineuzumab-Aβ Give Up Secrets

RESEARCH NEWS 2013-02-26 Research News Crystals of a bapineuzumab-Aβ complex may explain how the antibody targets amyloid plaques in the brain, according to researchers in Australia. In the February 18 Scientific Reports, Michael Parker and colleagues at St. Vincent's Instit

Linda Scheck

United States

Michelle Stonebrook

Senior Helpers of the Desert
Rancho Mirage, United States

Michael Detke

MedAvante & Indiana University School of Medicine
Carmel, United States

Lu Zhang

Pfizer Inc.
United States

Up-and-Coming ALS Mice Leave Scientists ConFUSed

CONFERENCE COVERAGE 2013-02-25 Conference Coverage Mouse engineers presented the latest models overexpressing the amyotrophic lateral sclerosis gene fused in sarcoma (FUS) at “New Frontiers in Neurodegenerative Disease Research,” a Keystone Symposium held 4-7 February 2013 in Santa Fe,

PAPER Schuepbach WM, Rau J, Knudsen K, Volkmann J, Krack P, Timmermann L, Hälbig TD, Hesekamp H, Navarro SM, Meier N, Falk D, Mehdorn M, Paschen S, Maarouf M, Barbe MT, Fink GR, Kupsch A, Gruber D, Schneider GH, Seigneuret E, Kistner A, Chaynes P, Ory-Magne F, Brefel Courbon C, Vesper J, Schnitzler A, Wojtecki L, Houeto JL, Bataille B, Maltête D, Damier P, Raoul S, Sixel-Doering F, Hellwig D, Gharabaghi A, Krüger R, Pinsker MO, Amtage F, Régis JM, Witjas T, Thobois S, Mertens P, Kloss M, Hartmann A, Oertel WH, Post B, Speelman H, Agid Y, Schade-Brittinger C, Deuschl G,

Neurostimulation for Parkinson's disease with early motor complications.

N Engl J Med. 2013 Feb 14;368(7):610-22. PubMed: 23406026

Isaac Sánchez Torres

National School of Biological Sciences
Mexico City, Mexico

PAPER Choi BK, Choi MG, Kim JY, Yang Y, Lai Y, Kweon DH, Lee NK, Shin YK

Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4087-92. PubMed: 23431141

PAPER Das A, Plotkin SS

SOD1 exhibits allosteric frustration to facilitate metal binding affinity.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3871-6. PubMed: 23431152

PAPER Watkins TA, Wang B, Huntwork-Rodriguez S, Yang J, Jiang Z, Eastham-Anderson J, Modrusan Z, Kaminker JS, Tessier-Lavigne M, Lewcock JW

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4039-44. Epub 2013 Feb 19 PubMed: 23431164

PAPER Pardo LM, Rizzu P, Francescatto M, Vitezic M, Leday GG, Sanchez JS, Khamis A, Takahashi H, van de Berg WD, Medvedeva YA, van de Wiel MA, Daub CO, Carninci P, Heutink P

Regional differences in gene expression and promoter usage in aged human brains.

Neurobiol Aging. 2013 Jul;34(7):1825-36. PubMed: 23428183

PAPER Wang H, Sun C, Liang Y, Zhang H, Tan Y

Identification of Regulatory Relationships in Parkinson's Disease.

J Mol Neurosci. 2013 Feb 21; PubMed: 23430405