PAPER Dong H, Wang S, Zeng Z, Li F, Montalvo-Ortiz J, Tucker C, Akhtar S, Shi J, Meltzer HY, Rice KC, Csernansky JG

Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice.

Psychopharmacology (Berl). 2014 Dec;231(24):4711-22. Epub 2014 May 27 PubMed: 24862368

PAPER Morinet F

Aging of the brain, dementias, role of infectious proteins: facts and theories.

Interdiscip Top Gerontol. 2014;39:177-86. Epub 2014 May 13 PubMed: 24862020

PAPER Li L, Wang W, Welford S, Zhang T, Wang X, Zhu X

Ionizing radiation causes increased tau phosphorylation in primary neurons.

J Neurochem. 2014 Oct;131(1):86-93. Epub 2014 Jun 16 PubMed: 24861936

PAPER Garwood CJ, Simpson JE, Al Mashhadi S, Axe C, Wilson S, Heath PR, Shaw PJ, Matthews FE, Brayne C, Ince PG, Wharton SB, MRC Cognitive Function and Ageing Study

DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort.

Neuropathol Appl Neurobiol. 2014 Dec;40(7):802-14. PubMed: 24861546

PAPER Robinson AC, Thompson JC, Weedon L, Rollinson S, Pickering-Brown S, Snowden JS, Davidson YS, Mann DM

No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease.

Neuropathol Appl Neurobiol. 2014 Dec;40(7):844-54. PubMed: 24861427

PAPER Mandler M, Walker L, Santic R, Hanson P, Upadhaya AR, Colloby SJ, Morris CM, Thal DR, Thomas AJ, Schneeberger A, Attems J

Pyroglutamylated amyloid-β is associated with hyperphosphorylated tau and severity of Alzheimer's disease.

Acta Neuropathol. 2014 Jul;128(1):67-79. Epub 2014 May 27 PubMed: 24861310

PAPER Meli G, Lecci A, Manca A, Krako N, Albertini V, Benussi L, Ghidoni R, Cattaneo A

Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum.

Nat Commun. 2014 May 27;5:3867. PubMed: 24861166

PAPER Furukawa K, Kamada M, Ishiki A, Tomita N, Arai H

[Clinical diagnosis].

Nihon Rinsho. 2014 Apr;72(4):667-72. PubMed: 24796095

PAPER Veronese S, Valle A, Chiò A, Calvo A, Oliver D

The last months of life of people with amyotrophic lateral sclerosis in mechanical invasive ventilation: A qualitative study.

Amyotroph Lateral Scler Frontotemporal Degener. 2014 May 27;:1-6. PubMed: 24863495

PAPER Lo AC, De Maeyer JH, Vermaercke B, Callaerts-Vegh Z, Schuurkes JA, D'Hooge R

SSP-002392, a new 5-HT4 receptor agonist, dose-dependently reverses scopolamine-induced learning and memory impairments in C57Bl/6 mice.

Neuropharmacology. 2014 Oct;85:178-89. Epub 2014 May 23 PubMed: 24863046

PAPER Kelly ME, Loughrey D, Lawlor BA, Robertson IH, Walsh C, Brennan S

The impact of exercise on the cognitive functioning of healthy older adults: a systematic review and meta-analysis.

Ageing Res Rev. 2014 Jul;16:12-31. Epub 2014 May 23 PubMed: 24862109

PAPER Chuong NN, Trung BH, Luan TC, Hung TM, Dang NH, Dat NT

Anti-amnesic effect of alkaloid fraction from Lycopodiella cernua (L.) Pic. Serm. on scopolamine-induced memory impairment in mice.

Neurosci Lett. 2014 Jul 11;575:42-6. Epub 2014 May 23 PubMed: 24861508

Andrew Wolf on PET Tracers Enlighten at Neurology Conference

COMMENT I agree with the comments from Dr. Rabinovici regarding ApoE possibly playing a multifactorial role in AD risk over the lifespan. In addition to the excellent articles by Huang and Mucke, and Jagust and Mormino, I would like to mention two reviews that I

Imme Thom on Art as Therapy—Can Creative Expression Soothe Dementia Symptoms?

COMMENT I am an art and sandplay therapist. I know that the potential of art for people who, for whatever reason, have lost the ability to express themselves clearly has not even been dreamed of. I have had success through art and sandplay, where all other method

Wataru Araki on Abundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease.

COMMENT The article by Guzman et al. provided immunohistochemical evidence that Aβ5-x, one of the N-truncated Aβ species, is more abundantly present in the brains of familial Alzheimer’s disease (FAD) cases than sporadic AD (SAD) cases. Vascular Aβ5-x immunoreact