RESEARCH NEWS 2015-07-31 Research News What goes wrong in the brain of a person with a hexanucleotide expansion in C9ORF72, a protein involved in RNA processing? Quite a bit, according to an analysis published in the July 20 Nature Neuroscience. Researchers from the Mayo Clinic ...
PAPER Prudencio M, Jansen-West KR, Lee WC, Gendron TF, Zhang YJ, Xu YF, Gass J, Stuani C, Stetler C, Rademakers R, Dickson DW, Buratti E, Petrucelli L
Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor.Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21510-5. Epub 2012 Dec 10 PubMed: 23236149
COMMENT I think the investment in ALS research is terrific and the organizers of the ALS ice bucket challenge are to be commended for their creativity and success in fund raising. We cannot think of research support as a competition among different tragic ...
SERIES Last year's ice bucket challenge for amyotrophic lateral sclerosis netted $220 million in donations for ALS charities, and the 2015 challenge is off to a strong start with $100,000 from Major League Baseball. Alzforum looks at how all that money is ...
COMMUNITY NEWS 2015-07-31 Community News Thanks to the ice bucket challenge for ALS, several clinical trials are picking up steam (see Part 1). However, as there are no guarantees these trials will succeed, ALS charities are also planning long-term. “We want to establish a ...
COMMUNITY NEWS 2015-07-31 Community News On July 31, 2014, former college baseball player Pete Frates uploaded a 52-second video to Facebook. Frates, who has amyotrophic lateral sclerosis, bobbed his head to the tune of “Ice Ice Baby.” While he stayed dry to protect his health, ...
PAPER McGrath MS, Kahn JO, Herndier BG12054081
PAPER Baranger K, Marchalant Y, Bonnet AE, Crouzin N, Carrete A, Paumier JM, Py NA, Bernard A, Bauer C, Charrat E, Moschke K, Seiki M, Vignes M, Lichtenthaler SF, Checler F, Khrestchatisky M, Rivera S
MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.Cell Mol Life Sci. 2015 Jul 23; PubMed: 26202697
PAPER Baek JH, Whitfield D, Howlett D, Francis P, Bereczki E, Ballard C, Hortobágyi T, Attems J, Aarsland D26202523
PAPER Radakovic R, Stephenson L, Colville S, Swingler R, Chandran S, Abrahams S26203157
PAPER Perera ND, Turner BJ26202426
PAPER Loureiro JA, Gomes B, Fricker G, Cardoso I, Ribeiro CA, Gaiteiro C, Coelho MA, Pereira MD, Rocha S26204501
PAPER Yang R, Jiang X, Ji R, Meng L, Liu F, Chen X, Xin Y26204407
PAPER Chow WN, Cheung HN, Li W, Lau KF26204394
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