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Diabetes Drug Improves Parkinson’s Motor Symptoms in Small Trial

RESEARCH NEWS 2017-08-17 Research News August brought some welcome news for the Parkinson’s community: results from a Phase 2 clinical trial suggested the diabetes drug exenatide halted the worsening of motor problems in people in moderate stages of the disease. As reported in ...

Shot of Klotho Boosts Memory In Aging and Diseased Mice

RESEARCH NEWS 2017-08-15 Research News Talk about instant gratification. According to an August 8 paper in Cell Reports, injecting a fragment of the protein klotho markedly improves memory and motor function in mice. Klotho is a protein associated with cognitive function in ...

The Search for the Missing AD Heritability Turns Up New Rare Variants

RESEARCH NEWS 2017-08-15 Research News Genetic forces drive a sizable portion of Alzheimer’s disease, yet only a fraction of cases thus far are explained by known mutations. A handful of recent papers used genomic sequencing to fish out new variants that, while exceedingly rare, ...

All Signs Point to Tau Tangles as the Culprit in Fading Memory

CONFERENCE COVERAGE 2017-08-12 Conference Coverage Part 2 of a two-part story. Click here for Part 1. The two hallmark pathologies of Alzheimer’s disease, amyloid plaques and tau tangles, play different roles in disease progression. Accumulating research suggests that amyloid plaques ...

CSF and Brain Markers Highlight Different Facets of Dementia

CONFERENCE COVERAGE 2017-08-12 Conference Coverage Part 1 of a two-part story. Click here for Part 2. While biomarkers have opened a window onto Alzheimer’s pathogenesis, the view has remained cloudy. At the Alzheimer’s Association International Conference 2017 held July 16-20 in ...

Edo Richard on New Dementia Trials to Test Lifestyle Interventions

COMMENT The results from FINGER show that its multidomain intervention, including cognitive training, leads to a small improvement of cognitive functioning in both the intervention and control condition over a 24-month period. The intervention group improved more ...

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