CONFERENCE COVERAGE 2017-08-23 Conference Coverage Part 2 of a two-part story. As longitudinal biomarker data begin to roll in, they challenge some previous assumptions about Alzheimer’s disease progression. Researchers at the Alzheimer’s Association International Conference 2017, held ...
PAPER Salat DH, Buckner RL, Snyder AZ, Greve DN, Desikan RS, Busa E, Morris JC, Dale AM, Fischl B15054051
COMMENT This is a very nice paper with clear experimental evidence that TIA-1 mutant proteins have reduced mobility, and alter stress granule disassembly. The finding that TIA-1 mutations alter stress granule disassembly reaffirms the idea that maintaining ...
COMMENT The article by Mackenzie et al. adds a new RNA-binding protein to the list of RNA-binding proteins that are linked to ALS and frontotemporal dementia. In one sense the article adds to the growing body of literature showing that dysfunction of RNA-binding ...
PAPER Sloan SA, Darmanis S, Huber N, Khan TA, Birey F, Caneda C, Reimer R, Quake SR, Barres BA, Paşca SP
Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.Neuron. 2017 Aug 16;95(4):779-790.e6. PubMed: 28817799
University College LondonUnited Kingdom
University of PennsylvaniaPhiladelphia, United States
Sichuan University, ChinaChengdu, China
Elko, United States
RESEARCH NEWS 2017-08-22 Research News In the August 16 Neuron, researchers led by Rosa Rademakers, Mayo Clinic, Jacksonville, Florida, and Paul Taylor, St. Jude Children’s Research Hospital, Memphis, Tennessee, report that mutations in the gene TIA1 cause amyotrophic lateral ...
Faculty of Medicine, University of Sao PauloSao Paulo, Brazil
CONFERENCE COVERAGE 2017-08-22 Conference Coverage Part 1 of a two-part story. As researchers analyze data in longitudinal biomarker studies, they find that some previously estimated biomarker trajectories do not hold up. At the Alzheimer’s Association International Conference 2017, ...
Lunenfeld-Tanenbaum Research InstituteToronto, Canada
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