Wai-Tong Chien on Stress and AD—The Cognition Connection

COMMENT It is very important and interesting to read Wilson and his colleagues' research on whether stress or proneness to distress is a risk factor for, or a sign of, cognitive decline. They acknowledged that the latter is possible, but favor the idea that

PAPER Caracciolo B, Bäckman L, Monastero R, Winblad B, Fratiglioni L

The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population.

J Neurol Neurosurg Psychiatry. 2011 Jul;82(7):788-93. PubMed: 21212108

Lawrence Friedhoff on Herpes Simplex and Alzheimer’s—Time to Think Again?

COMMENT I have been skeptical that abnormal β amyloid or tau were the primary cause of Alzheimer's disease for some time. As a person who led the development of the main drug used to treat the cognitive symptoms of the disease, it was my experience that disc

Chris Carter on Herpes Simplex and Alzheimer’s—Time to Think Again?

COMMENT Perhaps one of the important pieces of evidence is the high enrichment of herpes simplex binding proteins in plaques and tangles in the Alzheimer's disease brain, with p values rivaling those found in GWAS! (See Carter, 2010.) These structures also c

Melvyn Ball on Herpes Simplex and Alzheimer’s—Time to Think Again?

COMMENT Further to my Limbic-Predilection "Hypothesis" paper (Ball, 1982) suggesting HSV1 as a cause of AD, the key question that cell biologists must now answer is why neurofibrillary tangles always appear first in the aging and the demented person

Takaomi Saido on Power and pitfalls of the genome-wide association study approach to identify genes for Alzheimer's disease.

COMMENT Whole-genome sequencing should be the one. 0 saido

Takaomi Saido on Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy.

COMMENT This is a very important study. 0 saido

Takaomi Saido on Dissociation of apolipoprotein E oligomers to monomer is required for high-affinity binding to phospholipid vesicles.

COMMENT Interesting. 0 saido

Torik Ayoubi

KU Leuven
Leuven, Belgium

PAPER Sweatt JD

Neuroscience. Creating stable memories.

Science. 2011 Feb 18;331(6019):869-70. PubMed: 21330525

PAPER Barco A, Lopez de Armentia M, Alarcon JM

Synapse-specific stabilization of plasticity processes: the synaptic tagging and capture hypothesis revisited 10 years later.

Neurosci Biobehav Rev. 2008;32(4):831-51. PubMed: 18281094

PAPER Frey U, Morris RG

Synaptic tagging: implications for late maintenance of hippocampal long-term potentiation.

Trends Neurosci. 1998 May;21(5):181-8. PubMed: 9610879

PAPER Galef BG, Whiskin EE

Socially transmitted food preferences can be used to study long-term memory in rats.

Learn Behav. 2003 May;31(2):160-4. PubMed: 12882374

Do Synaptic Tags Code Memories for Storage?

RESEARCH NEWS 2011-02-22 Research News Despite decades of research, much about how our memory works remains a mystery. How does an evening at a concert become a cherished recollection? How is that memory encoded and where is it stored? Scientists believe that the hippocampus orch

Cindy Keith

State College, United States