PAPER Vos SJ, van Rossum IA, Verhey F, Knol DL, Soininen H, Wahlund LO, Hampel H, Tsolaki M, Minthon L, Frisoni GB, Froelich L, Nobili F, van der Flier W, Blennow K, Wolz R, Scheltens P, Visser PJ
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PAPER Burns JM, Swerdlow RH
Backwaters and rapids on the amyloid river.
Neurology. 2013 Mar 5;80(10):878-9. PubMed: 23446682PAPER Jack CR, Wiste HJ, Lesnick TG, Weigand SD, Knopman DS, Vemuri P, Pankratz VS, Senjem ML, Gunter JL, Mielke MM, Lowe VJ, Boeve BF, Petersen RC
Brain β-amyloid load approaches a plateau.
Neurology. 2013 Mar 5;80(10):890-6. PubMed: 23446680Alena Savonenko on Inducible APP Mice—Cognition Restored in Advanced Amyloidosis?
COMMENT The interpretation of preclinical findings for human disease must always be careful. It is intriguing that all measurable Aβ species, including soluble Aβ42, remained unchanged after transgene suppression. The deposited amyloid could be a reservoir that l
Alena Savonenko
Johns Hopkins MedicineUnited States
Karen Hsiao Ashe on Inducible APP Mice—Cognition Restored in Advanced Amyloidosis?
COMMENT Regarding the conundrum of cognitive improvement despite lingering Aβ oligomers in the inducible APP mice, there are several issues to discuss. First, it may be premature to consider the immunoreactive smears to be Aβ oligomers. Neither 6E10 (Figs. 6A, B)
PAPER Melnikova T, Fromholt S, Kim H, Lee D, Xu G, Price A, Moore BD, Golde TE, Felsenstein KM, Savonenko A, Borchelt DR
Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis.
J Neurosci. 2013 Feb 27;33(9):3765-79. PubMed: 23447589Lars-Olof Wahlund on Spinal Fluid Flush: Visualizing the Brain Drain With MRI
COMMENT It is a very interesting paper and proposes a new way for the brain to get rid of waste products. It can increase our knowledge in how Aβ is metabolized in the brain/body, something we need to know much more about to be able to fully understand the pathol
Lars-Olof Wahlund
Karolinska InstitutetSweden
1996-1997 Scientific Advisory Board
Other Carl Cotman, Ph.D. Director, Institute for Brain Aging and Dementia University of California, Irvine Joseph Coyle Eben S. Draper Professor of Psychiatry and Neuroscience Harvard Medical School Peter Davies Albert Einstein College of Medicine, Scientific D
PAPER Nabavi S, Kessels HW, Alfonso S, Aow J, Fox R, Malinow R
Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression.
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4027-32. PubMed: 23431133PAPER Cummings JA, Mulkey RM, Nicoll RA, Malenka RC
Ca2+ signaling requirements for long-term depression in the hippocampus.
Neuron. 1996 Apr;16(4):825-33. PubMed: 8608000PAPER Cho K, Aggleton JP, Brown MW, Bashir ZI
An experimental test of the role of postsynaptic calcium levels in determining synaptic strength using perirhinal cortex of rat.
J Physiol. 2001 Apr 15;532(Pt 2):459-66. PubMed: 11306664PAPER Bröcher S, Artola A, Singer W
Intracellular injection of Ca2+ chelators blocks induction of long-term depression in rat visual cortex.
Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):123-7. PubMed: 1309603PAPER Ferrer-Acosta A, Rodriguez-Cruz EN, Vaquer-Alicea AC, Vega IE
Functional and Structural Analysis of the Conserved EFhd2 Protein.
Protein Pept Lett. 2012 Sep 4; PubMed: 22973849Current Filters
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