FDA Approves a Second Amyloid Imaging Agent

RESEARCH NEWS 2013-11-21 Research News The U.S. Food and Drug Administration on October 25 approved a second amyloid imaging agent. Flutemetamol, renamed Vizamyl, is an F18-labeled ligand developed by GE Healthcare. It joins florbetapir, or Amyvid, developed by Avid Pharmaceutica

‘Godfather of Tau’ Skip Binder Dies at 63

COMMUNITY NEWS 2013-11-21 Community News Colleagues, friends, and family of Lester “Skip” Binder are mourning his sudden passing on November 15, a month shy of his 64th birthday. Known to his fellow researchers as “The Godfather of Tau,” Binder was among the first to recognize tha

PAPER Zu T, Liu Y, Bañez-Coronel M, Reid T, Pletnikova O, Lewis J, Miller TM, Harms MB, Falchook AE, Subramony SH, Ostrow LW, Rothstein JD, Troncoso JC, Ranum LP

RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4968-77. Epub 2013 Nov 18 PubMed: 24248382

PAPER Hardy J, Rogaeva E

Motor neuron disease and frontotemporal dementia: sometimes related, sometimes not.

Exp Neurol. 2013 Nov 15; PubMed: 24246281

PAPER Phillipson OT

Management of the aging risk factor for Parkinson's disease.

Neurobiol Aging. 2014 Apr;35(4):847-57. Epub 2013 Oct 10 PubMed: 24246717

PAPER Wu AG, Wong VK, Xu SW, Chan WK, Ng CI, Liu L, Law BY

Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells.

Int J Mol Sci. 2013 Nov 15;14(11):22618-41. PubMed: 24248062

PAPER He Q, Yu W, Wu J, Chen C, Lou Z, Zhang Q, Zhao J, Wang J, Xiao B

Intranasal LPS-mediated Parkinson's model challenges the pathogenesis of nasal cavity and environmental toxins.

PLoS One. 2013;8(11):e78418. Epub 2013 Nov 8 PubMed: 24250796

PAPER Bialystok E, Craik FI, Binns MA, Ossher L, Freedman M

Effects of bilingualism on the age of onset and progression of MCI and AD: evidence from executive function tests.

Neuropsychology. 2014 Mar;28(2):290-304. Epub 2013 Nov 18 PubMed: 24245925

PAPER Gaudreau G, Monetta L, Macoir J, Laforce R Jr, Poulin S, Hudon C

Verbal irony comprehension in older adults with amnestic mild cognitive impairment.

Neuropsychology. 2013 Nov;27(6):702-12. PubMed: 24245931

PAPER Sim A, Tsagkrasoulis D, Montana G

Random forests on distance matrices for imaging genetics studies.

Stat Appl Genet Mol Biol. 2013 Dec;12(6):757-86. PubMed: 24246292

PAPER Zhang T, Xu W, Mu Y, Derreumaux P

Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicity.

ACS Chem Neurosci. 2014 Feb 19;5(2):148-59. Epub 2013 Nov 22 PubMed: 24246047

PAPER Harris SE, Davies G, Luciano M, Payton A, Fox HC, Haggarty P, Ollier W, Horan M, Porteous DJ, Starr JM, Whalley LJ, Pendleton N, Deary IJ

Polygenic risk for Alzheimer's disease is not associated with cognitive ability or cognitive aging in non-demented older people.

J Alzheimers Dis. 2014;39(3):565-74. PubMed: 24246418

PAPER Moore EM, Ames D, Mander AG, Carne RP, Brodaty H, Woodward MC, Boundy K, Ellis KA, Bush AI, Faux NG, Martins RN, Masters CL, Rowe CC, Szoeke C, Watters DA

Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: combined data from three cohorts.

J Alzheimers Dis. 2014;39(3):661-8. PubMed: 24246419

PAPER Paajanen T, Hänninen T, Tunnard C, Hallikainen M, Mecocci P, Sobow T, Tsolaki M, Vellas B, Lovestone S, Soininen H

CERAD neuropsychological compound scores are accurate in detecting prodromal alzheimer's disease: a prospective AddNeuroMed study.

J Alzheimers Dis. 2014;39(3):679-90. PubMed: 24246420

PAPER Yanagisawa D, Taguchi H, Ibrahim NF, Morikawa S, Shiino A, Inubushi T, Hirao K, Shirai N, Sogabe T, Tooyama I

Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.

J Alzheimers Dis. 2014;39(3):617-31. PubMed: 24246421