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Massive GWAS Reveals 40 New “Intelligence” Genes

RESEARCH NEWS 2017-05-26 Research News Genome-wide association studies (GWAS) have pinpointed genetic variations associated with various human traits, even complex ones influenced by multiple genes, such as height. But finding robust ties to intelligence has proven elusive. By ...

PAPER Benyamin B, Pourcain B, Davis OS, Davies G, Hansell NK, Brion MJ, Kirkpatrick RM, Cents RA, Franić S, Miller MB, Haworth CM, Meaburn E, Price TS, Evans DM, Timpson N, Kemp J, Ring S, McArdle W, Medland SE, Yang J, Harris SE, Liewald DC, Scheet P, Xiao X, Hudziak JJ, de Geus EJ, Wellcome Trust Case Control Consortium 2 (WTCCC2), Jaddoe VW, Starr JM, Verhulst FC, Pennell C, Tiemeier H, Iacono WG, Palmer LJ, Montgomery GW, Martin NG, Boomsma DI, Posthuma D, McGue M, Wright MJ, Davey Smith G, Deary IJ, Plomin R, Visscher PM

Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.

Mol Psychiatry. 2014 Feb;19(2):253-8. Epub 2013 Jan 29 PubMed: 23358156

Do Perivascular Macrophages Mediate Aβ Pathology?

RESEARCH NEWS 2017-05-26 Research News Amyloid-β is bad news for neurons, and also for the blood vessels that feed them. Now, a study from the lab of Costantino Iadecola, Weill Cornell Medical College in New York, proposes an unexpected role for perivascular macrophages (PVMs) as ...

DIAN-TU Fellowship Opportunity

JOB 2017-05-26 Employer Washington University School of Medicine Principal Investigator Randall Bateman Contact batemanr@wustl.edu Description The DIAN-TU launched the first anti-amyloid Alzheimer’s prevention trials platform with two drugs and a third drug launching in ...

Certain Cancer Drugs Held Out as Prospects for ALS Therapy

RESEARCH NEWS 2017-05-26 Research News Could tyrosine kinase inhibitors, a standard tool of cancer treatment, help people with amyotrophic lateral sclerosis? Converging evidence suggests that this drug class may slow ALS progression, perhaps through multiple mechanisms. In the ...

PAPER Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, Kunath T, Wray S, Furuya H, Era T, Makioka K, Okamoto K, Fujisawa T, Nishitoh H, Homma K, Ichijo H, Julien JP, Obata N, Hosokawa M, Akiyama H, Kaneko S, Ayaki T, Ito H, Kaji R, Takahashi R, Yamanaka S, Inoue H

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.

Sci Transl Med. 2017 May 24;9(391) PubMed: 28539470

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