CONFERENCE COVERAGE 2016-08-30 Conference Coverage In the quest to find biomarkers that detect presymptomatic Alzheimer’s disease, some researchers are turning to measures of brain connectivity. Many studies have reported that functional circuits become disorganized early in the ...
PAPER Summerfield JJ, Hassabis D, Maguire EA18973817
PAPER Yeo BT, Krienen FM, Sepulcre J, Sabuncu MR, Lashkari D, Hollinshead M, Roffman JL, Smoller JW, Zöllei L, Polimeni JR, Fischl B, Liu H, Buckner RL21653723
PAPER Tijms BM, Seriès P, Willshaw DJ, Lawrie SM21878484
COMMENT The paper by Wey et al. on PET imaging of HDACs appears to provide an important new proof of principle, showing that key epigenetic regulators can be imaged in human brain. There is growing evidence that class I HDACs play important roles in a highly ...
RESEARCH NEWS 2016-08-30 Research News Scientists are working out whether inhibitors of particular enzymes in one histone deacetylase (HDAC) family may one day restore normal transcription of genes in certain neurodegenerative disorders. Until now, though, they have been unable ...
PAPER Wang C, Schroeder FA, Wey HY, Borra R, Wagner FF, Reis S, Kim SW, Holson EB, Haggarty SJ, Hooker JM
In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs.J Med Chem. 2014 Oct 9;57(19):7999-8009. Epub 2014 Sep 18 PubMed: 25203558
PAPER De Beaumont L, Pelleieux S, Lamarre-Théroux L, Dea D, Poirier J, and the Alzheimer’s Disease Cooperative Study
Butyrylcholinesterase K and Apolipoprotein E-ɛ4 Reduce the Age of Onset of Alzheimer's Disease, Accelerate Cognitive Decline, and Modulate Donepezil Response in Mild Cognitively Impaired Subjects.J Alzheimers Dis. 2016 Aug 18; PubMed: 27567841
PAPER Shankle WR, Hara J, Barrentine LW, Curole MV
CerefolinNAC Therapy of Hyperhomocysteinemia Delays Cortical and White Matter Atrophy in Alzheimer's Disease and Cerebrovascular Disease.J Alzheimers Dis. 2016 Aug 24; PubMed: 27567825
PAPER Gertje EC, Pluta J, Das S, Mancuso L, Kliot D, Yushkevich P, Wolk D
Clinical Application of Automatic Segmentation of Medial Temporal Lobe Subregions in Prodromal and Dementia-Level Alzheimer's Disease.J Alzheimers Dis. 2016 Aug 18; PubMed: 27567809
PAPER Yoshino Y, Mori T, Yoshida T, Yamazaki K, Ozaki Y, Sao T, Funahashi Y, Iga JI, Ueno SI27567856
PAPER Lauzé M, Daneault JF, Duval C27567884
PAPER Jenkins A, Lindsay S, Eslambolchilar P, Thornton IM, Tales A27567875
PAPER Boehm-Cagan A, Bar R, Liraz O, Bielicki JK, Johansson JO, Michaelson DM27567858
No filters selected