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Second Trial of Diaphragm Pacing for ALS Shuts Down

RESEARCH NEWS 2015-09-01 Research News A second clinical trial of a diaphragm pacer for people with ALS has shut down early, and another hangs in limbo, as doctors and patients wonder if the surgically implanted device—meant to improve breathing—does more harm than good. ...

Enter Aη: Alternative APP Cleavage Creates Synaptotoxic Peptide

RESEARCH NEWS 2015-08-31 Research News Aβ42 has hogged the limelight in Alzheimer’s research, but growing evidence suggests that other fragments derived from amyloid precursor protein deserve close attention. Today in Nature, researchers led by Christian Haass at the German ...

PAPER Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C

η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

Nature. 2015 Aug 31; PubMed: 26322584

BRAIN Initiative: Technology Sharing and Propagation (R03)

GRANT Monday, August 31, 2015- 10:45 National Institute of Mental Health, National Center for Complementary and Integrative Health, National Eye Institute, National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute of ...

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