PAPER Liu R, Gao X, Lu Y, Chen H
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Sanjay Pimplikar on Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.
COMMENT It is a healthy sign that the paper by Winton et al. has initiated a debate over intraneuronal Aβ, as more studies are appearing in the literature suggesting that intraneuronal Aβ could play a pathological role in Alzheimer’s disease (AD). This issue can
Iris Oren
UCL Insitute of NeurologyLondon
Feeding Frenzy—Therapeutics Tap Tryptophan, Cathepsins, HDACs, Zinc
RESEARCH NEWS 2011-06-10 Research News Feeling sleepy? The amino acid behind the dreaded drowsiness that sets in after a big meal makes headlines in today’s Cell, where researchers report that tweaking a tryptophan degradation pathway with an oral compound relieved behavioral def
Are People With Parkinson’s at Higher Risk for Melanoma?
RESEARCH NEWS 2011-06-10 Research News Neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease are typically linked to a lower risk of getting cancer, but a new study shows there are exceptions to this rule. Researchers led by Honglei Chen at the National
PAPER Wang Q, Werstiuk NH, Kramer JR, Bell RA
Effects of Cu ions and explicit water molecules on the copper binding domain of amyloid precursor protein APP(131-189): a molecular dynamics study.
J Phys Chem B. 2011 Jul 28;115(29):9224-35. PubMed: 21648462PAPER Giunta B, Ehrhart J, Obregon DF, Lam L, Le L, Jin J, Fernandez F, Tan J, Shytle RD
Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: implications for HIV-associated neurocognitive disorders.
Mol Brain. 2011;4(1):23. PubMed: 21649911PAPER
Bradycardia due to cholinesterase inhibitors: identify adverse effects and take them into account.
J Neurosci Res. 2011 Oct;89(10):1542-50. PubMed: 21648211PAPER Presećki P, Mück-Seler D, Mimica N, Pivac N, Mustapić M, Stipcević T, Smalc VF
Serum lipid levels in patients with Alzheimer's disease.
Coll Antropol. 2011 Jan;35 Suppl 1:115-20. PubMed: 21648320PAPER Henigsberg N, Kalember P, Hrabać P, Rados M, Bajs M, Kovavić Z, Loncar M, Madzar T
1-H MRS changes in dorsolateral prefrontal cortex after donepezil treatment in patients with mild to moderate Alzheimer's disease.
Coll Antropol. 2011 Jan;35 Suppl 1:159-62. PubMed: 21648328PAPER Ohara T, Ninomiya T, Kubo M, Hirakawa Y, Doi Y, Hata J, Iwaki T, Kanba S, Kiyohara Y
Apolipoprotein genotype for prediction of Alzheimer's disease in older Japanese: the Hisayama Study.
J Am Geriatr Soc. 2011 Jun;59(6):1074-9. PubMed: 21649613PAPER de Boer ME, Dröes RM, Jonker C, Eefsting JA, Hertogh CM
Advance directives for euthanasia in dementia: how do they affect resident care in Dutch nursing homes? Experiences of physicians and relatives.
J Am Geriatr Soc. 2011 Jun;59(6):989-96. PubMed: 21649621Alan Lipschitz
MerckNorth Wales, United States
Vincent Marchesi on Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.
COMMENT How can mice with so many genetic defects possibly reflect the pathophysiology of the earliest, asymptomatic, pre-amyloid accumulation stages of human AD? If this question cannot be answered positively and persuasively, it matters little what form of APP
Zhiping Pang on Direct conversion of human fibroblasts to dopaminergic neurons.
COMMENT It's nice to see other groups reproduce our data about the conversion of human neurons directly from fibroblasts, and extend it to a linage-specific stage. Morphologically, the tyrosine hydroxylase-positive-induced neuronal cells converted by BAM+LF
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