Wave of New BACE Inhibitors Heading to Phase 2

CONFERENCE COVERAGE 2012-07-27 Conference Coverage Many had trouble reaching the brain. Or they got in but couldn’t stay, ousted in short order by P-glycoprotein. At long last, drug developers have overcome these and other hurdles, and well over a decade of effort developing β-secretas

Makoto Ishii

Weill Medical College of Cornell University
New York, United States

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Tracing Aβ’s Toxicity Through Prion Protein, Fyn Kinase

RESEARCH NEWS 2012-07-27 Research News Oligomers are widely believed to be the most neurotoxic Aβ species, but how they exert their harmful effects remains mysterious. Previously, researchers led by Stephen Strittmatter at Yale University, New Haven, Connecticut, reported that at

PAPER O'Callaghan C, Hodges JR, Hornberger M

Inhibitory Dysfunction in Frontotemporal Dementia: A Review.

Alzheimer Dis Assoc Disord. 2012 Jul 20; PubMed: 22828322

PAPER Dara C, Kirsch-Darrow L, Ochfeld E, Slenz J, Agranovich A, Vasconcellos-Faria A, Ross E, Hillis AE, Kortte KB

Impaired emotion processing from vocal and facial cues in frontotemporal dementia compared to right hemisphere stroke.

Neurocase. 2012 Jul 25; PubMed: 22827701

PAPER Furukawa Y

Pathological roles of wild-type cu, zn-superoxide dismutase in amyotrophic lateral sclerosis.

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PAPER Zhao Y, Luo P, Guo Q, Li S, Zhang L, Zhao M, Xu H, Yang Y, Poon W, Fei Z

Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo.

Exp Neurol. 2012 Oct;237(2):489-98. PubMed: 22828134

PAPER Lettieri Barbato D, Baldelli S, Pagliei B, Aquilano K, Ciriolo MR

Caloric Restriction and the Nutrient-Sensing PGC-1α in Mitochondrial Homeostasis: New Perspectives in Neurodegeneration.

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PAPER Ishigaki S, Masuda A, Fujioka Y, Iguchi Y, Katsuno M, Shibata A, Urano F, Sobue G, Ohno K

Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions.

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PAPER Levine TD, Bowser R, Hank NC, Gately S, Stephan D, Saperstein DS, Van Keuren-Jensen K

A Pilot Trial of Pioglitazone HCl and Tretinoin in ALS: Cerebrospinal Fluid Biomarkers to Monitor Drug Efficacy and Predict Rate of Disease Progression.

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PAPER Ransome MI, Renoir T, Hannan AJ

Hippocampal neurogenesis, cognitive deficits and affective disorder in Huntington's disease.

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Molecular Chaperones and Co-Chaperones in Parkinson Disease.

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Adult neurogenesis and neural stem cells as a model for the discovery and development of novel drugs.

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