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Taisuke Tomita on New Role For PICALM: Flushing Aβ From the Brain

COMMENT CALM/PICALM is one of the most abundant clathrin adaptors in endocytic clathrin-coated vesicles and regulates the endocytic process at presynaptic active zones of neurons (Blondeau et al., 2004; Koo et al., 2011). Regarding the pathological aspect of ...

New Role For PICALM: Flushing Aβ From the Brain

RESEARCH NEWS 2015-05-29 Research News Genome-wide association studies have fingered PICALM as a consistent link to Alzheimer’s disease. The protein promotes clathrin-mediated endocytosis and has been tied to APP processing and increased Aβ production in neurons. In the May 25 ...

Anna Santacruz

Washington University School of Medicine
St. Louis, United States

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