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Kinase inhibitors modulate huntingtin cell localization and toxicity.

Nat Chem Biol. 2011 Jul;7(7):453-60. PubMed: 21623356

PAPER Krobitsch S, Lindquist S

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins.

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Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes.

Hum Mol Genet. 2009 Jul 15;18(14):2683-92. PubMed: 19403559

PAPER Mayne J, Dewpura T, Raymond A, Bernier L, Cousins M, Ooi TC, Davignon J, Seidah NG, Mbikay M, Chrétien M

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture.

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PAPER Bittles AH, Neel JV

The costs of human inbreeding and their implications for variations at the DNA level.

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PAPER Uzumcu A, Norgett EE, Dindar A, Uyguner O, Nisli K, Kayserili H, Sahin SE, Dupont E, Severs NJ, Leigh IM, Yuksel-Apak M, Kelsell DP, Wollnik B

Loss of desmoplakin isoform I causes early onset cardiomyopathy and heart failure in a Naxos-like syndrome.

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The characterization of twenty sequenced human genomes.

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Huntington’s Strategies Tap Transcription, Htt Phosphorylation

RESEARCH NEWS 2012-02-20 Research News Two potential approaches for tackling Huntington’s disease come to the fore in this week’s literature—an intriguing mechanism begging for a drug, and a promising compound with an unknown mechanism. In the February 17 Cell, researchers led by

Are Broken Genes Common in Humans?

RESEARCH NEWS 2012-02-20 Research News Previous genome studies suggest that all of us possess a few hundred non-functional genes. Is this number accurate, and if so, what does it mean for human health? In the February 17 Science, a large international group led by Daniel MacArthu

Mariana Urse

Romania

PAPER Haacke EM, Beggs CB, Habib C

The role of venous abnormalities in neurological disease.

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PAPER Gass J, Prudencio M, Stetler C, Petrucelli L

Progranulin: An emerging target for FTLD therapies.

Brain Res. 2012 Jan 28; PubMed: 22338605

PAPER Flight MH

Neurodegenerative disease: Harnessing virus-mediated mitochondrial protection to combat neurodegeneration.

Nat Rev Drug Discov. 2012 Mar;11(3):188-9. PubMed: 22338641

PAPER d'Avila JC, Lam TI, Bingham D, Shi J, Won SJ, Kauppinen TM, Massa S, Liu J, Swanson RA

Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor.

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Calcium signaling in dendritic spines.

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