PAPER Ohara T, Ninomiya T, Kubo M, Hirakawa Y, Doi Y, Hata J, Iwaki T, Kanba S, Kiyohara Y
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PAPER de Boer ME, Dröes RM, Jonker C, Eefsting JA, Hertogh CM
Advance directives for euthanasia in dementia: how do they affect resident care in Dutch nursing homes? Experiences of physicians and relatives.
J Am Geriatr Soc. 2011 Jun;59(6):989-96. PubMed: 21649621Alan Lipschitz
MerckNorth Wales, United States
Vincent Marchesi on Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.
COMMENT How can mice with so many genetic defects possibly reflect the pathophysiology of the earliest, asymptomatic, pre-amyloid accumulation stages of human AD? If this question cannot be answered positively and persuasively, it matters little what form of APP
Zhiping Pang on Direct conversion of human fibroblasts to dopaminergic neurons.
COMMENT It's nice to see other groups reproduce our data about the conversion of human neurons directly from fibroblasts, and extend it to a linage-specific stage. Morphologically, the tyrosine hydroxylase-positive-induced neuronal cells converted by BAM+LF
Zhiping Pang
Child Health Institute of New JerseyNew Brunswick, United States
PAPER Pfisterer U, Kirkeby A, Torper O, Wood J, Nelander J, Dufour A, Björklund A, Lindvall O, Jakobsson J, Parmar M
Direct conversion of human fibroblasts to dopaminergic neurons.
Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10343-8. PubMed: 21646515Steven Brenner on Combined administration of D-galactose and aluminium induces Alzheimer-like lesions in brain.
COMMENT This is potentially a good Alzheimer's model. There may be a number of different toxins or chemicals that contribute to development of Alzheimer's disease. D-galactose is also important as an aging model, and together, aluminum and D-galactose c
Suzanne Guenette on Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells.
COMMENT This paper shows that human embryonic stem (hES) cells overexpressing amyloid precursor protein (APP) display a robust differentiation towards a neural fate. APP-overexpressing H9 and HUES7 hES cells behaved similarly. Soluble APP fragments (sAPP) were sh
Sanjay Pimplikar on Comparison of effect sizes associated with biomarkers reported in highly cited individual articles and in subsequent meta-analyses.
COMMENT The remarkable, if not entirely surprising, findings reported in this paper should be of interest to the readers of Alzforum because of the current excitement in the field about "AD biomarkers." As summarized above, the study by Ioannidis and Pa
PAPER Kraft P
Curses--winner's and otherwise--in genetic epidemiology.
Epidemiology. 2008 Sep;19(5):649-51; discussion 657-8. PubMed: 18703928PAPER Ioannidis JP
Why most discovered true associations are inflated.
Epidemiology. 2008 Sep;19(5):640-8. PubMed: 18633328PAPER Ioannidis JP
Contradicted and initially stronger effects in highly cited clinical research.
JAMA. 2005 Jul 13;294(2):218-28. PubMed: 16014596PAPER Young NS, Ioannidis JP, Al-Ubaydli O
Why current publication practices may distort science.
PLoS Med. 2008 Oct 7;5(10):e201. PubMed: 18844432Amy Duffield on Risk factors and preventive interventions for Alzheimer disease: state of the science.
COMMENT Given the importance of magnesium (Mg) to brain function (Slutsky et al., 2010), it would seem to make sense to make sure older people are getting enough of this critical mineral. Mg plays an important role in protein kinases. Tyrosine-specific protein ki
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