PAPER Srivastava G, Dixit A, Yadav S, Patel DK, Prakash O, Singh MP
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PAPER Lugert S, Vogt M, Tchorz JS, Müller M, Giachino C, Taylor V
Homeostatic neurogenesis in the adult hippocampus does not involve amplification of Ascl1(high) intermediate progenitors.
Nat Commun. 2012;3:670. PubMed: 22334073PAPER Shigetomi E, Tong X, Kwan KY, Corey DP, Khakh BS
TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.
Nat Neurosci. 2012 Jan;15(1):70-80. PubMed: 22158513PAPER Konno M, Shirakawa H, Iida S, Sakimoto S, Matsutani I, Miyake T, Kageyama K, Nakagawa T, Shibasaki K, Kaneko S
Stimulation of transient receptor potential vanilloid 4 channel suppresses abnormal activation of microglia induced by lipopolysaccharide.
Glia. 2012 May;60(5):761-70. PubMed: 22331560PAPER Walterfang M, Macfarlane MD, Looi JC, Abel L, Bowman E, Fahey MC, Desmond P, Velakoulis D
Pontine-to-midbrain ratio indexes ocular-motor function and illness stage in adult Niemann-Pick disease type C.
Eur J Neurol. 2012 Mar;19(3):462-7. PubMed: 22329857Maria Björkqvist
Lund UniversitySweden
Thomas Pochapsky on α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.
COMMENT We shouldn’t lose sight of the most important aspect of this controversy, which is that α-synuclein can, and does, take on different forms in response to the local environment, and likely occupies multiple states in vivo. In other words, it is a moving ta
Michael K. Lee on α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.
COMMENT The report from the collaborative Lashuel group is a careful but partial rebuttal of two recent reports (Bartels et al., 2011 and Wang et al., 2011) that concluded that α-synuclein in cells exists as a stable tetramer. In the current report, Fauvet et al.
Thomas Pochapsky
Brandeis UniversityWaltham, United States
Michael Ewers on Subjective cognition and amyloid deposition imaging: a Pittsburgh Compound B positron emission tomography study in normal elderly individuals.
COMMENT The study by Perrotin et al. shows that subtle decreases in memory and an accompanying awareness of reduced memory performance is associated with higher PIB-PET imaging of β amyloid (Aβ) in the brains of asymptomatic, cognitively normal elders. In view of
Michael Ewers
University of California, San FranciscoSan Francisco, United States
Pat McGeer on Upping Brain ApoE, Drug Treats Alzheimer's Mice
COMMENT The report by Cramer et al. is potentially exciting because it offers a plausible explanation as to why ApoE4 should be a risk factor for AD, and more importantly suggests that bexarotene, an off-the-shelf retinoid X receptor agonist, may prove to be an e
Claudia Schwab
University of Bristish ColumbiaVancouver, Canada