Texas Tech Health Science CenterLubbok, United States
JOB 2017-05-22 Employer Imperial College London Contact firstname.lastname@example.org Description Imperial College London is seeking a postdoc who would like to use an exciting molecular delivery technology developed in its laboratory to treat Alzheimer’s disease modeled in a ...
RESEARCH NEWS 2017-05-20 Research News Textbook diagrams of the brain’s basal ganglia often represent their component nuclei as monolithic blocks, but a study in the May 8 Nature Neuroscience now shows how their finer substructures may harbor therapeutic opportunities. By ...
PAPER Adamchic I, Hauptmann C, Barnikol UB, Pawelczyk N, Popovych O, Barnikol TT, Silchenko A, Volkmann J, Deuschl G, Meissner WG, Maarouf M, Sturm V, Freund HJ, Tass PA24976001
PAPER Wang J, Nebeck S, Muralidharan A, Johnson MD, Vitek JL, Baker KB
Coordinated Reset Deep Brain Stimulation of Subthalamic Nucleus Produces Long-Lasting, Dose-Dependent Motor Improvements in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Non-Human Primate Model of Parkinsonism.Brain Stimul. 2016 Jul-Aug;9(4):609-17. Epub 2016 Mar 22 PubMed: 27151601
PAPER Tass PA, Qin L, Hauptmann C, Dovero S, Bezard E, Boraud T, Meissner WG23280797
PAPER Mastro KJ, Bouchard RS, Holt HA, Gittis AH
Transgenic mouse lines subdivide external segment of the globus pallidus (GPe) neurons and reveal distinct GPe output pathways.J Neurosci. 2014 Feb 5;34(6):2087-99. PubMed: 24501350
PAPER Corbit VL, Whalen TC, Zitelli KT, Crilly SY, Rubin JE, Gittis AH
Pallidostriatal Projections Promote β Oscillations in a Dopamine-Depleted Biophysical Network Model.J Neurosci. 2016 May 18;36(20):5556-71. PubMed: 27194335
PAPER Mallet N, Pogosyan A, Márton LF, Bolam JP, Brown P, Magill PJ
Parkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activity.J Neurosci. 2008 Dec 24;28(52):14245-58. PubMed: 19109506
PAPER Mastro KJ, Zitelli KT, Willard AM, Leblanc KH, Kravitz AV, Gittis AH28481350
COMMENT This is a very well-designed study and a strength is that they use a population-based approach with detailed clinical characterization of the patients identified from the medical record. The comparison of survival among different clinical phenotypes of ...
COMMENT Dr. Grutzendler’s group found that Nissl dye NeuroTrace 500/525 specifically labels brain capillary pericytes in living mice. This dye can stain Pdgfrb and NG2-expressing cells on capillaries, but not precapillary or arteriolar αSMA-expressing cells. ...
COMMENT As shown previously for dextran-conjugated calcium green or FluoroGold injected into the blood (Hirase et al., 2004; Edwards et al., 2013), this paper shows that some capillary pericytes can be loaded with exogenously applied dye (in this case the Nissl ...
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