PAPER Kim JW, Lee DY, Seo EH, Sohn BK, Park SY, Choo IH, Youn JC, Jhoo JH, Kim KW, Woo JI

Improvement of dementia screening accuracy of mini-mental state examination by education-adjustment and supplementation of frontal assessment battery performance.

J Korean Med Sci. 2013 Oct;28(10):1522-8. PubMed: 24133360

PAPER Goodall EF, Heath PR, Bandmann O, Kirby J, Shaw PJ

Neuronal dark matter: the emerging role of microRNAs in neurodegeneration.

Front Cell Neurosci. 2013;7:178. PubMed: 24133413

PAPER Mitew S, Kirkcaldie MT, Dickson TC, Vickers JC

Neurites containing the neurofilament-triplet proteins are selectively vulnerable to cytoskeletal pathology in Alzheimer's disease and transgenic mouse models.

Front Neuroanat. 2013;7:30. PubMed: 24133416

Ann McKee on Functional MRI Detects Brain Abnormalities in Former Football Players

COMMENT This is a noteworthy report that is the first to demonstrate functional MRI abnormalities in retired NFL players. The anatomical areas where frontal lobe hyperactivation and hypoconnectivity were found line up extremely well with the areas of structural d

Sam Gandy on Functional MRI Detects Brain Abnormalities in Former Football Players

COMMENT For five decades, chronic traumatic encephalopathy (CTE), formerly known as dementia pugilistica, was exclusively associated with delayed neurodegeneration with prominent tauopathy. The clinical syndromes varied from pure dementia to parkinsonism without

PAPER Hideyama T, Yamashita T, Aizawa H, Tsuji S, Kakita A, Takahashi H, Kwak S

Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons.

Neurobiol Dis. 2012 Mar;45(3):1121-8. PubMed: 22226999

PAPER Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE

Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion.

Neuroimage. 2012 Feb 1;59(3):2142-54. PubMed: 22019881

PAPER Belanger HG, Spiegel E, Vanderploeg RD

Neuropsychological performance following a history of multiple self-reported concussions: a meta-analysis.

J Int Neuropsychol Soc. 2010 Mar;16(2):262-7. PubMed: 20003581

PAPER Golub MS, Germann SL, Lloyd KC

Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse.

Behav Brain Res. 2004 Aug 12;153(1):159-70. PubMed: 15219717

PAPER Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R, Lemke G

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor.

Nature. 1995 Nov 23;378(6555):390-4. PubMed: 7477376

PAPER Takahashi Y, Fukuda Y, Yoshimura J, Toyoda A, Kurppa K, Moritoyo H, Belzil VV, Dion PA, Higasa K, Doi K, Ishiura H, Mitsui J, Date H, Ahsan B, Matsukawa T, Ichikawa Y, Moritoyo T, Ikoma M, Hashimoto T, Kimura F, Murayama S, Onodera O, Nishizawa M, Yoshida M, Atsuta N, Sobue G, , Fifita JA, Williams KL, Blair IP, Nicholson GA, Gonzalez-Perez P, Brown RH, Nomoto M, Elenius K, Rouleau GA, Fujiyama A, Morishita S, Goto J, Tsuji S

ERBB4 Mutations that Disrupt the Neuregulin-ErbB4 Pathway Cause Amyotrophic Lateral Sclerosis Type 19.

Am J Hum Genet. 2013 Oct 8; PubMed: 24119685

Ahmed Kassem

University of Pittsburgh
United States

Richard Ransohoff on Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) by ectodomain shedding and γ-secretase dependent intramembranous cleavage.

COMMENT As far as it goes, this paper is quite provocative. The main limitations are that the experiments were done in artificial cell lines and used transfected molecular components. It should be possible, based on these findings, to demonstrate abnormalities of

PAPER McFarland K, Spalding TA, Hubbard D, Ma JN, Olsson R, Burstein ES

Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson's Disease.

ACS Chem Neurosci. 2013 Oct 11; PubMed: 24117438

PAPER Sjölander A, Andersson ME, Zetterberg H, Minthon L, Bogdanovic N, Blennow K

Alzheimer's disease: No effect of the CDK5 gene on CSF biomarkers, neuropathology or disease risk.

Mol Med Rep. 2009 Nov-Dec;2(6):989-92. PubMed: 21475932