University of PennsylvaniaPhiladelphia, United States
William McEwan on TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.
COMMENT This is a very interesting paper centered on TRIM28, which was found by phenotypic screens to stabilize tau and α-synuclein and promote their nuclear localization. TRIM28 is a member of the TRIM family, of which there are ~100 in the human genome. We have ...
CONFERENCE 2017-05-08 00:00:00-2017-05-09 00:00:00 Montreal, Canada 08 – 09 May 2017 Research on dementia and cognition has experienced a rapid growth in the last 20 years. It addresses a great diversity of questions and scientific approaches, ranging from animals to humans. This symposium will ...
Fen-Biao Gao on Toxic PRn poly-dipeptides encoded by the C9orf72 repeat expansion block nuclear import and export.
COMMENT This study examined the biochemical interaction between poly(PR) and the nuclear pore. They found that poly(PR) binds to polymeric forms of the FG repeat domain found in several nuclear pore proteins, providing molecular mechanistic insight into the ...
Instituto de Neuroartes
Wicking Dementia Research and Education CentreHobart, Australia
BioArctic ABStockholm, Sweden
COMMENT "Amplification bias" is certainly an issue that needs to be considered when fibril structures from brain tissue are amplified by seeded growth. Certain structures may self-propagate more efficiently than others, depending on the precise details ...
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