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Aldo Pagano on RNA polymerase III drives alternative splicing of the potassium channel-interacting protein contributing to brain complexity and neurodegeneration.
COMMENT In agreement with Christian Haass, I recommend prudence in linking, unequivocally, the forced expression of 38A ncRNA to the pathological manifestations of AD. We must be cautious in ascribing to its over-synthesis a causative mechanism of AD onset. In th
Hui Zheng on Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells.
COMMENT This paper presents two interesting findings. One is that expression of APP in human embryonic stem cells (hESCs) robustly promotes neuronal differentiation. The other is that this effect is mediated by soluble APP (sAPP) and that sAPPβ is more potent tha
Lars Nilsson on Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.
COMMENT The study by Winton et al. is a well-designed study that provides important new information on a frequently used animal model of Alzheimer’s disease. However, based on the results presented, I would be cautious to conclude that intraneuronal Aβ accumulati
Se Hoon Choi
Massachusetts General HospitalCharlestown, United States
PAPER Silveri MC, Ciccarelli N, Cappa A
Unilateral spatial neglect in degenerative brain pathology.
Neuropsychology. 2011 Sep;25(5):554-66. PubMed: 21639641PAPER Tsujimoto M, Senda J, Ishihara T, Niimi Y, Kawai Y, Atsuta N, Watanabe H, Tanaka F, Naganawa S, Sobue G
Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging.
J Neurol Sci. 2011 Aug 15;307(1-2):34-40. PubMed: 21641004PAPER Martin I, Dawson VL, Dawson TM
Recent advances in the genetics of Parkinson's disease.
Annu Rev Genomics Hum Genet. 2011 Sep 22;12:301-25. PubMed: 21639795PAPER Kim YM, Jang WH, Quezado MM, Oh Y, Chung KC, Junn E, Mouradian MM
Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation.
J Neurol Sci. 2011 Aug 15;307(1-2):157-61. PubMed: 21641618PAPER Lu J, Ng KC, Ling G, Wu J, Poon DJ, Kan EM, Tan MH, Wu YJ, Li P, Moochhala S, Yap E, Lee LK, Teo M, Yeh IB, Sergio DM, Chua F, Kumar SD, Ling EA
Effect of Blast Exposure on the Brain Structure and Cognition in Macaca fascicularis.
J Neurotrauma. 2011 Nov 7; PubMed: 21639720PAPER Iseri PK, Karson A, Gullu KM, Akman O, Kokturk S, Yardýmoglu M, Erturk S, Ates N
The effect of memantine in harmaline-induced tremor and neurodegeneration.
Neuropharmacology. 2011 Sep;61(4):715-23. PubMed: 21640732PAPER Dribben WH, Creeley CE, Farber N
Low-level lead exposure triggers neuronal apoptosis in the developing mouse brain.
Neurotoxicol Teratol. 2011 Jul-Aug;33(4):473-80. PubMed: 21640820PAPER März-Weiss P, Kunz D, Bimmler D, Berkemeier C, Özbek S, Dimitriades-Schmutz B, Haybaeck J, Otten U, Graf R
Expression of pancreatitis-associated protein after traumatic brain injury: a mechanism potentially contributing to neuroprotection in human brain.
Cell Mol Neurobiol. 2011 Nov;31(8):1141-9. PubMed: 21643999PAPER Nerurkar PV, Johns LM, Buesa LM, Kipyakwai G, Volper E, Sato R, Shah P, Feher D, Williams PG, Nerurkar VR
Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation.
J Neuroinflammation. 2011;8:64. PubMed: 21639917PAPER Hashimoto K, Hayashi Y, Watabe K, Inuzuka T, Hozumi I
Metallothionein-III prevents neuronal death and prolongs life span in amyotrophic lateral sclerosis model mice.
Neuroscience. 2011 Aug 25;189:293-8. PubMed: 21640795Current Filters
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