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Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic.
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Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.
Cell. 2013 Dec 5;155(6):1351-64. Epub 2013 Nov 27 PubMed: 24290359PAPER Tanaka S, Ishii A, Ohtaki H, Shioda S, Yoshida T, Numazawa S
Activation of microglia induces symptoms of Parkinson's disease in wild-type, but not in IL-1 knockout mice.
J Neuroinflammation. 2013 Dec 1;10:143. PubMed: 24289537Current Filters
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