Research Models

Tg-mAPP/DN-RAGE

Synonyms: mAPP/DN-RAGE, APP/DN-RAGE

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Species: Mouse
Genes: APP, RAGE
Mutations: APP KM670/671NL (Swedish), APP V717F (Indiana)
Modification: APP: Transgenic; RAGE: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: C57BL/6
Availability: Available through Shirley ShiDu Yan.

Neuropathology

Bigenic mice expressing dominant-negative RAGE as well as mutant APP displayed diminished neuropathology compared with mice expressing mutant APP alone, including the area occupied by acetylcholinesterase-positive fibers in the subiculum at three to four and 14 to 18 months of age (Arancio et al., 2004).

Cognition/Behavior

Bigenic mice displayed preservation of spatial learning and memory compared with Tg-mAPP/RAGE animals (Arancio et al., 2004).

Other Phenotypes

No abnormalities were reported with respect to reproductive fitness, development, basic neurological functioning, or longevity (Arancio et al., 2004).

Modification Details

Mice expressing a dominant-negative form of RAGE comprising a truncated form of the receptor with intact extracellular and membrane-spanning portions, but a deleted cytosolic tail driven by the PDGF-β promoter were crossed with mice expressing human APP carrying the Swedish and Indiana mutations driven by PDGF-β promoter (The Jackson Lab: Stock# 004661--now extinct).

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References

Research Models Citations

  1. Tg-mAPP/RAGE

Paper Citations

  1. . RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. EMBO J. 2004 Oct 13;23(20):4096-105. PubMed.

Other Citations

  1. Shirley ShiDu Yan

External Citations

  1. The Jackson Lab: Stock# 004661

Further Reading