Research Models
Selected Results
1 Models
| Name | Other Names | Strain Name | Genetic Background | Gene | Mutation | Modification Info | Modification | Disease | Neuropathology | Behavior/Cognition | Other Phenotype | Availability | Primary Paper | Visualization | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mouse Models (1) |
|||||||||||||||
| line G9, H163R mutant PS-1 YAC, B6-G9, PS1-YAC | B6.129S4-Tg(PSEN1H163R)G9Btla/J | Origin: 129S4/SvJae, backcrossed to C57BL/6 | PSEN1 | PSEN1 H163R | A 1000 kb YAC transgene (788H12) containing the entire human PSEN1 gene with the H163R mutation. Transgene also has ~550 kb of upstream and 350 kb of downstream flanking sequences. | PSEN1: Transgenic | Alzheimer's Disease | Elevated Aβ42 in the brain and plasma. Higher levels and earlier Aβ deposition when crossed with APP YAC line R1.40. | Unknown. | Alternatively spliced human PSEN1 transcripts. | The Jackson Lab: Stock# 006469; Cryopreserved | Lamb et al., 1999 | No | ||