Modification: PSEN1: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: Mixed C57BL/6J, DBA/2J
Availability: No longer available
These mice express wild-type human PSEN1. Compared with mice expressing similar levels of human PSEN1 with the P117L mutation (i.e. PSEN1(P117L), expression of wild-type PSEN1 was associated with increased survival and differentiation of neural progenitor cells in the hippocampus, leading to the generation of more immature granule cells (Wen et al., 2002).
Human wild-type PSEN1 driven by neuron-specific enolase (NSE).
Research Models Citations
- Wen PH, Shao X, Shao Z, Hof PR, Wisniewski T, Kelley K, Friedrich VL, Ho L, Pasinetti GM, Shioi J, Robakis NK, Elder GA. Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice. Neurobiol Dis. 2002 Jun;10(1):8-19. PubMed.
- Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Exp Neurol. 2004 Aug;188(2):224-37. PubMed.