Posted:	1/9/2013
Job Title:	Postdoctoral Position: Autophagy in Neurodegeneration
Employer:	Hoffmann-La Roche (Basel, Switzerland)/Karolinska Institutet (Stockholm, Sweden)
Description:	This postdoc position is available through the Roche Postdoctoral Fellowship (RPF) program, which supports outstanding young scientists to work on research collaborations between Roche and international academic institutions. As Roche Postdoctoral Fellow, the successful candidate will receive scientific mentoring from both Roche and its academic partners and gain valuable research experience from both academic and industrial perspectives. This 2-year temporary position will be based at the Karolinska Institutet (Pr Caroline Graff, Stockholm, Sweden) but the RPF will have the opportunity to conduct some of the experimental work at Roche in Basel, Switzerland. The project will include: analysis of the autophagy pathway in brain tissue from individuals diagnosed with tauopathies from the Brain Bank at Karolinska Institutet; using iPSC-derived neurons from Alzheimer disease patients to investigate how tau and phosphorylated tau could impair the autophagy-lysosomal pathway.
Requirements:	In hiring new employees, we look for people who are also inspired by our mission and who would fit in well with the collaborative, rigorous and entrepreneurial spirit of the company culture. Because we know that employees are critical to our success in bringing novel medicines to patients, we are dedicated to remaining a great place to work and to providing employees with programs, services and benefits that allow them to bring the best to the business and to their personal lives. You have: a PhD in cell biology or neurobiology with a thorough understanding of the mechanisms regulating the clearance of aggregate-prone proteins, in particular the autophagy pathway; extensive practical experience with state-of-the-art light microscopy imaging and image processing techniques and should be familiar with protein and organelle labeling methods; hands-on experience in working with iPSC-derived neurons is an advantage; high motivation, strong organizational skills and ablility to solve problems creatively; excellent oral and written communication skills in English are required.
Contact:	All applicants should directly apply at http://careers.roche.com/ and search for Job ID: 00410192.