Posted:	11/9/2012
Job Title:	Postdoctoral Position Studying Neurodegeneration
Employer:	Emory University, Atlanta, Georgia
Description:	Two postdoctoral fellowship positions are available immediately to study the mechanisms of neurodegeneration and development of new therapeutic approaches. There are two postdoc positions available to investigate: 1. the processing of APP by beta and γ-secretase to produce the amyloid-β peptide and its role in Alzheimer's disease. We are investigating the mechanism and therapeutic use of compounds called γ-secretase modulators (GSMs) using mouse models, cell culture, and chemical biology. 2. Loss of the progranulin (PGRN) protein leads to frontotemporal dementia. Variants in the PGRN gene appear to increase the risk of Alzheimer's disease. We are investigating the biological function of PGRN in the CNS using knockout mice, primary cultures, and high throughput genomics and proteomics.
Requirements:	Applicants with a PhD or MD are encouraged to apply. Experience in modern molecular and cellular biology is strongly desired. Experience with primary neuronal cultures, mouse models, DNA arrays, or proteomics is a plus, but not required. Good spoken and written English skills are encouraged. Strong writing skills are highly desirable.
Contact:	Tom Kukar, Ph.D. Assistant Professor Emory University Department of Pharmacology 1510 Clifton Rd NE 5123 Rollins Research Center Atlanta, GA 30322-3090 Office: 404-727-5991