Therapeutic implications
It is important to aggressively pursue the therapeutic opportunities afforded by the evidence that AD pathogenesis is likely to be initiated by changes in Aß42.
- It will be important to check the effect of potential therapeutic agents on both extracelllar and intracellular Aß since, at the moment, it is unclear which compartment is most important.
- Drugs selectively affecting one compartment or the other may have effects that are highly informative in the search for effective therapy.