Why hasn’t Aß been shown to accumlate intracellularly in AD?
1. Intracellular aggregates or fibrils that would be detectable may grow rapidly resulting in swift cellular degeneration, so that detectable intracellular aggregates may rarely be present.
- If this process occurs primarily within neurites, it could cause very little loss of neuronal perikarya until the process is quite advanced.
- Synaptic loss could also be difficult to detect in the early stages, if, as is quite likely, damage to a small % of neurites results in impressive extracellular Aß deposition.