Role of Intracellular Aß42 in AD
Thus, the genetic changes that increase extracellular Aß42 could increase intracellular Aß42 at the time of its intracellular production, following reuptake, or through both mechanisms.
Given the apparently higher concentration of Aß in the intracellular organelles that contain Aß and their lower pH compared to the extracellular compartment, it is highly likely that Aß aggregation and fibril formation begin in the intracellular compartment.