Role of Intracellular Aß42 in AD

Although it remains to be proven, it is likely that the genetic changes that increase extracellular secreted Aß42 will also increase intraluminal Aß42 in at least some organelle involved in Aß secretion, thereby favoring intracellular fibril formation.
- A study by C. Haass’ group has already reported increased intracellular Aß42 in association with an APP717 mutation.

Although it remains to be proven, it is likely that the genetic changes that increase extracellular secreted Aß42 will also increase intraluminal Aß42 in at least some organelle involved in Aß secretion, thereby favoring intracellular fibril formation.