Aß42, plaques, and/or tangles could be markers only

Trisomy 21; FAD-linked PS1,

PS2, or APP mutations

Increased

extracellular Aß42

Extracellular Aß42 deposition

Senile plaques

Neurofibrillary

tangles

Dementia and other

clincal symptoms

Neuron and

synapse loss

????? - e. g. a

change that

causes enhanced

susceptibility

to apoptosis

(Reactive oxygen species, “inflammation”)

Previous slide

Next slide

Back to first slide

View graphic version