Role of Aß42 in AD
In this case, increased extracellular Aß42, Aß deposition, plaques, and tangles could all be excellent markers for another process that causes AD as shown in the following figure.
- It should be noted that Aß aggregates are toxic to neurons, Aß triggers the classic complement cascade, and Aß provokes a significant microglial response.
- Thus, it is unlikely that Aß plays no role in AD pathogenesis, but its role might be minor.