Extracellular Aß deposition may trigger a pathological cascade that causes AD

Trisomy 21; FAD-linked PS1,

PS2, or APP mutations

Increased

extracellular Aß42

Extracellular Aß42 deposition

Senile plaques

Neurofibrillary

tangles

Dementia and other

clincal symptoms

Neuron and

synapse loss

(Reactive oxygen species, “inflammation”)

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