Role of Aß42 in AD

• Trisomy 21 and the many PS1, PS2, and ßAPP mutations linked to early onset familial AD all increase the extracellular concentration of Aß42 or of both Aß40 and Aß42.

  • There is a broad consensus for this based on studies of plasma and fibroblasts from patients, transfected cells, and transgenic mice.
    • Thus, a fundamental effect of all genetic forms of AD is to increase the extracellular concentration of Aß42 - a change that will foster the extracellular Aß deposition that is invariably observed in AD.

Previous slide

Next slide

Back to first slide

View graphic version