Updated 5 November 2002
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The Presenilins
By Bart DeStrooper
View Bart DeStrooper's presentation
Abstract: This presentation focuses on the cell biology
of the presenilins. The role of presenilins in the cleavage
of type I integral membrane proteins, the turn-over of beta-catenin
and possibly other functions in trafficking and Ca2+ signaling
are discussed. The novel proteins associated with the gamma-secretase
complex are presented.
For a detailed review the reader is
referred to "A
Cell Biological Perspective on Alzheimer's Disease"
published in Annu Rev Cell Dev Biol. 2002 May 16 [epub ahead
of print].
(Photo courtesy of Medialink for the Alzheimer's Association.)
View Bart DeStrooper's presentation
To hear the associated audio, click on the "Play Audio" button on each slide.
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