This conference took place in Philadelphia, Pennsylvania, USA, on 17 - 22 July, 2004. Listen to the speakers and view their presentations by clicking on the links below. See related news related to the conference. Download Free Quicktime Player.

Presentations

Laura Fratiglioni: Psychosocial Risk Factors
A psychosocial factor may be defined as a measurement that potentially relates psychological phenomenon to the social environment and to physical changes. The psychosocial component of dementia and cognitive disturbances is a rapidly developing field, but the research evidence is still scarce. Psychosocial factors that have been related to dementia and AD are: personality, life events, work-life stress, leisure activity, social network and socio-economical status.... Click here for more.

M. Flint Beal: Oxidative Mechanisms, Inflammation, and Alzheimer's Disease Pathogenesis
There is a large body of evidence implicating oxidative damage in the pathogenesis of Alzheimer's disease. We previously identified increased concentration of 8-hydroxy-2-deoxyguanosine in both nuclear and mitochondrial DNA of Alzheimer's disease patients. We found a three-fold increase in the amount of oxidative damage to mitochondrial DNA as compared to age-matched controls. Click here for more.

Domenico Pratico: Biomarkers of Alzheimer's disease: F2-isoprostanes
AD is the most common, complex, and challenging neurodegenerative disease associated with dementia in the elderly. Besides the pathological hallmarks of the disease, which include senile plaques and neurofibrillary tangles, AD brain exhibits evidence of reactive oxygen species (ROS)-mediated damage. Click here for more.

Lindsey Farrer: Using a Genetic Approach to Understand the Vascular Basis of Alzheimer Disease
There is a growing body of evidence from pathological and epidemiological studies that risk factors for vascular disease also enhance risk of AD. Objectives: To evaluate the association between genes involved in vascular function and susceptibility to AD in Caucasian and African American families in the MIRAGE Study and in Wadi Ara, an inbred Israeli-Arab community with a high prevalence of AD. Click here for more.

William Mobley: Trafficking the Target-Derived Signals of Neurotrophic Factors: Implications for Normal and Degenerating Neuronse
Elucidating the cellular mechanisms that build and maintain synaptic connections is required for understanding normal and abnormal nervous system function. The neurotrophins (NTs) are a family of neurotrophic factors that act to influence the development and maintenance of neurons. Understanding their physiological roles requires that we elucidate how NT signals generated in the target of innervation are moved retrogradely to cell bodies to regulate cytosolic and nuclear events. Click here for more.

News Reports

• The Enemy Within—Neurodegeneration From Intraneuronal Aβ
  
• Diagnosis Light—Toward Infrared Plaques
  
• All Eyes on PIB Imaging—Is It Coming Along?
  
• Dementia Types Just Won’t Fit into Little Boxes
  
• Can a Shrinking Brain Be Good for You?
  
• Mom Was Right. Eat Your Carrots!
  
• All Is Not Well with the Statin Story
  

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