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Anti-Inflammatory Drug Use and Risk of Incident Alzheimer's Disease in a Defined
L. A. Beckett,* D. A. Bennett, T. Field, and D. A. Evans
Rush Institute on Aging, Rush University, Chicago, Illinois 60612, USA,
and Brigham and Women's Hospital, Harvard University, Boston, Massachusetts,
Note: Laurel Beckett's talk will not be recorded.
The authors examined the effects of anti-inflammatory drugs on the risk
of incident Alzheimer's disease (AD) in a prospective community-based study.
Previous studies suggest that inflammatory and immune mechanisms may be
involved in AD and that anti-inflammatory drug use may lower disease risk
or slow progression. However, few studies used direct examination of medications
or examined incident disease. In this study, an unaffected cohort of 2,313
persons aged 65 years and older was identified from the population of East
Boston, Massachusetts, and followed for a mean of 4.3 years. Drug use at
baseline (1982) was determined by direct examination of all medications
used in the preceding 2 weeks. A stratified sample of 642 persons received
detailed clinical examination at follow-up; 238 had used one or more anti-inflammatory
drugs. Risk of developing AD was similar among users and nonusers of anti-inflammatory
drugs overall. In weighted logistic regression controlled for age, sex,
length of follow-up, education, and sampling design, the estimated odds
ratio of AD for anti-inflammatory drugs users was 0.98 (95% confidence interval
0.48-2.02) compared with nonusers. Disease risk was also similar for users
and nonusers of the two major subgroups of these drugs. The risk for users
of salicylates compared to nonusers was 0.80 (95% confidence interval 0.36-1.80),
and the risk for users of nonsalicylate, nonsteroidal anti-inflammatory
agents compared to nonusers was 1.28 (95% confidence interval 0.49-3.36).
These results do not support a large protective effect of these drugs on
risk of AD.
Supported by National Institute on Aging, AG02107, AG12106, AG10161.