In concluding I hope that I have convinced you that the picture is not that simple as the amyloid cascade hypothesis. That activity or rather neuronal inactivity is a key factor in Alzheimer's disease. In my opinion it also is the only explanation of how in the early stages of Alzheimer's disease the symptoms can change from day to day and from hour to hour when we observe patients. It's remarkable how rapidly these symptoms can change. So this cannot be based on sliver stained anatomical changes. It should be an activity-related phenomena at least in the early stages. I tried to indicate that high affinity neurotrophin receptors may be a key factor in the early changes and that reactivation might be possible if you only know the right stimulus for a neuronal system.